【摘要】 目的 分析上尿路尿酸结石与代谢综合征(metabolic syndrome,MetS)的关系。方法 回顾性分析了莒南县人民医院、青岛大学附属医院、临沂市肿瘤医院共计939例上尿路结石患者,使用结石光谱自动分析系统将结石分为含尿酸类结石、含钙类结石、感染性结石、其他类型结石。按MetS诊断标准将患者分为MetS组及非MetS组,比较两组患者所患结石成分的差异。结果 MetS组中尿酸类结石明显高于非MetS组(32.58%vs 17.66%),差异有统计学意义(P<0.001)。非MetS组中钙类结石及感染性结石明显高于MetS组,差异有统计学意义。多因素logistics分析显示,代谢综合征相比较非代谢综合征患者发生尿酸类结石的风险高2.22倍(95%CI1.59～3.11,P<0.001),其中腹型肥胖、高血糖、甘油三酯(triacylglycerol,TG)升高、高密度脂蛋白(high density lipoprotein,HDL)降低是尿酸结石形成的危险因素。结论 上尿路尿酸结石与MetS密切相关,腹型肥胖、高血糖、高TG、低HDL是尿酸结石形成的危险因素。更多还原

【Abstract】 Objective To explore the correlation between uric acid stones in the upper urinary tract and metabolic syndrome(MetS).Methods A total of 939 patients with upper urinary tract stones from the Junan County People’s Hospital,The Affiliated Hospital of Qingdao University,and Linyi Tumor Hospital were evaluated.All stones were analyzed using a stone spectrum automatic analysis system,and the stone components were classified into uric acid stones,calcium stones,infectious stones,and other types of stones.All patients were divided into MetS and non-MetS groups according to the MetS criteria,and the differences in stone components between the two groups were compared.Results The number of uric acid stones in the MetS group was significantly higher than that in the non-MetS group(32.58% vs.17.66%,P<0.001).The numbers of calcium and infectious stones in the non-MetS group were significantly higher than those in the MetS group.Multivariate logistic analysis showed that the risk of having uric acid stones in patients with MetS was 2.22 times higher than that in patients with non-MetS(95% confidence interval:1.59-3.11,P<0.001).Abdominal obesity,hyperglycemia,high TG,and low HDL were identified as the risk factors for the formation of uric acid stones.Conclusion Multicenter upper urinary tract uric acid stones are closely related to MetS.Abdominal obesity,hyperglycemia,high TG,and low HDL are the risk factors for the formation of uric acid stones.更多还原