【摘要】 临床上主要采用血液灌流技术治疗高胆红素血症，但血液灌流树脂的血液相容性较差，且由于治疗过程中需要介入血浆分离器，增加了治疗风险和治疗成本.本文创新性地研制了一种具有一步“滤过-吸附”双功能的新型聚氯乙烯(PVC)改性膜，通过傅里叶红外光谱、X射线光电子能谱分析和扫描电镜等测试手段研究了膜的化学结构和形貌，测试原膜与改性膜的基本性能，并对原膜与改性膜的胆红素吸附能力，凝血性和溶血性进行了表征.结果表明，二乙烯三胺被成功接枝到膜表面，接枝改性后，改性膜的表面和断面结构未发生明显改变，最大分离孔径为0.27μm,牛血清白蛋白筛分率达94%,纯水通量达445 L/(m~2·h),胆红素吸附率达60%,溶血率小于5%,不会引起溶血反应，凝血时间和纤维蛋白原与空白对照组相比无明显变化，不会激起凝血反应.更多还原

【Abstract】 The main clinical treatment for hyperbilirubinemia is hemoperfusion technique, but the blood compatibility of hemoperfusion resin is poor. The need of plasma separator during treatment increases the risk of treatment and the cost of treatment. Therefore, this paper creatively developed a new type of polyvinyl chloride(PVC) modified membrane with one-step “filtration adsorption” function. The chemical structure and morphology of the membrane were studied by means of Fourier infrared spectroscopy, X-ray photoelectron spectroscopy and scanning electron microscopy, the basic properties of the original membrane and modified membrane were tested, and the bilirubin adsorption capacity, coagulability and hemolysis of the original membrane and modified membrane were characterized. The results showed that diethylenetriamine was successfully grafted onto the membrane surface. After grafting modification, the surface and cross-section structure of the modified membrane did not change significantly, and the maximum separation pore size was 0.27 μm, the screening rate of bovine serum albumin was 94%, the pure water flux was 445 L/(m~2·h), the adsorption rate of bilirubin was 60%. The hemolysis rate was less than 5%, which would not cause hemolysis reaction. There was no significant change in coagulation time and fibrinogen compared with the blank control group, and would not arouse coagulation reaction.更多还原