【摘要】 组学新技术新方法的不断涌现和突破，加快了组学研究高通量、定量化发展。将一种或多种高通量组学技术联合生物信息学对生物样本或数据进行分析，挖掘生物分子及其功能之间的联系，可为疾病机制研究提供更全面、更多层次的见解。转录组学、蛋白组学、代谢组学及其联合分析在皮肤疾病的病因研究、疾病鉴别诊断与辅助诊断、生物标志物与新型治疗靶点发现以及药物治疗反应等方面发挥着重要作用。本文回顾近年转录组学、蛋白组学和代谢组学及其联合分析在皮肤领域的应用研究。更多还原

【Abstract】 With the continuous emergence and breakthrough of new technologies and methods, the omics research has accelerated the development of high-throughput quantification. To reveal the mechanisms of disease in a comprehensive and multi-faceted manner, integration of one or more high-throughput omics technologies with bioinformatics has been used to analyze biological samples or data to reveal the link between biomolecules and their functions. Transcriptomics, proteomics, metabolomics and their combined analyses have made important contributions to the investigation of the etiology of skin diseases, differential and complementary diagnosis, discovery of biomarkers and novel therapeutic targets, as well as response to drug treatments. In the article, we review the applications of transcriptome, proteomics, metabonomics, and combined-analysis in dermatology.更多还原