术后帕瑞昔布钠注射与术中肋间神经阻滞在胸腔镜肺叶切除术后镇痛的疗效比较

【摘要】 目的 比较术后帕瑞昔布钠注射与术中肋间神经阻滞在胸腔镜肺叶切除术后的镇痛效果。方法 选取2019年6月至2020年11月行全身麻醉胸腔镜肺叶切除的非小细胞肺癌患者80例，随机分为对照组和观察组。对照组在手术即将结束关闭胸腔前进行胸腔内罗哌卡因肋间神经阻滞，观察组在术后即刻及术后6 h静脉注射帕瑞昔布钠镇痛，观察术后1 h、6 h、12 h、24 h疼痛视觉模拟评分（VAS）以及追加镇痛药物情况和术后不良反应的发生情况。结果 观察组VAS评分在术后1 h、6 h、24 h与对照组比较差异无统计学意义（P>0.05）；观察组术后12 h VAS评分低于对照组（P<0.05）；术后对照组和观察组恶心、呕吐发生率差异无统计学意义（P>0.05）。结论 术后静脉注射帕瑞昔布钠镇痛疗效优于罗哌卡因术中肋间神经阻滞。更多还原

【Abstract】 Objective To compare the analgesic effect of parecoxib sodium injection after operation and intercostal nerve block during operation after thoracoscopic lobectomy. Methods Eighty patients with non-small cell lung cancer who underwent thoracoscopic lobectomy under general anesthesia in Shaoxing Second Hospital from June 2019 to November 2020 were randomly divided into control group and experimental group. The control group received intrathoracic ropivacaine intercostal nerve block just before closing the thoracic cavity at the end of the operation,while the experimental group received intravenous parecoxib sodium for analgesia immediately after operation and 6 hours after operation. The visual analogue score(VAS) were observed at 1,6,12,24 hours after operation, additional analgesic drugs and the occurrence of postoperative adverse reactions were observed. Results The VAS scores of the experimental group at 1 hour after operation,6 hours after operation and 24 hours after operation had no significant differences compared with the control group(P>0.05). The VAS score of the experimental group at 12 hours after operation was lower than that of the control group(P<0.05). There was no significant difference in the incidence of nausea and vomiting between the control group and the experimental group(P>0.05). Conclusion The analgesic effect of intravenous parecoxib sodium after operation is better than that of ropivacaine during intercostal nerve block.更多还原