【摘要】 目的 分析乙型肝炎病毒(hepatitis B virus, HBV)相关肝硬化病人前S1抗原(Pre-S1 antigen, PreS1Ag)、乙型肝炎表面抗原(hepatitis B surface antigen, HBsAg)水平及PreS1Ag/HBsAg的比值，对HBV相关肝硬化病人肝癌发生风险的影响。方法 2019年3月～2021年4月合肥市第一人民医院收治HBV相关肝硬化肝癌病人61例，未发生肝癌的HBV相关肝硬化病人61例，检测所有受试者PreS1Ag、HBsAg水平及PreS1Ag/HBsAg比值，建立Logistic回归预测模型分析HBV相关肝硬化病人PreS1Ag、HBsAg水平及PreS1Ag/HBsAg比值对肝癌发生风险的影响，采用ROC曲线、决策曲线对模型进行预测效力及临床实用性评价。结果 HBV相关肝硬化病人PreS1Ag、HBsAg及PreS1Ag/HBsAg比值分别为(112.36±20.47)ng/ml、(3.67±0.29)log IU/ml和(1.14±0.20);Logistic回归分析显示，年龄、HBsAg、PreS1Ag、PreS1Ag/HBsAg是HBV相关肝硬化病人肝癌发生风险的危险因素，ROC曲线分析，多因素Logistic回归分析结果建立预测模型，结果显示，HBsAg、PreS1Ag、PreS1Ag/HBsAg在预测HBV相关肝硬化病人肝癌发生均具临床价值。结论 年龄、HBsAg、PreS1Ag、PreS1Ag/HBsAg是HBV相关肝硬化病人肝癌发生危险因素，HBsAg、PreS1Ag、PreS1Ag/HBsAg预测HBV相关肝硬化病人肝癌发生均具临床价值。更多还原

【Abstract】 Objective To evaluate the levels of Pre-S1 antigen(PreS1 Ag),Hepatitis B surface antigen(HBsAg) and PreS1 Ag/HBsAg levels, and to explore the effect of PreS1 Ag/HBsAg levels on the risk of hepatocellular carcinoma in patients with HBV-related cirrhosis.Methods From March 2019 to April 2021,61 HBV-related liver cirrhosis patients in First People’s Hospital of Hefei and 61 HBV-related liver cirrhosis patients without liver cancer from March 2019 to April 2021 were retrospectively enrolled.PreS1 Ag/HBsAg levels, a logistic regression prediction model was established to analyze the effects of PreS1 Ag, HBsAg levels and PreS1 Ag/HBsAg levels on the risk of liver cancer in patients with HBV-related cirrhosis, and the ROC curve and decision curve were used to evaluate the predictive efficacy and clinical practicability of the model.Results The levels of PreS1 Ag, HBsAg and PreS1 Ag/HBsAg in patients with HBV-related cirrhosis were(112.36±20.47) ng/ml,(3.67±0.29) log IU/ml, and 1.14±0.20,respectively; Logistic regression analysis showed that age,HBsAg, PreS1 Agand PreS1 Ag/HBsAg were risk factors for the risk of liver cancer in patients with HBV-related cirrhosis.ROC curve analysis showed that a predictive model was established based on multivariate Logistic regression analysis results.The results showed that HBsAg, PreS1 Ag, and PreS1 Ag/HBsAg had clinical value in predicting the occurrence of liver cancer in patients with HBV-related cirrhosis.Conclusion Age, HBsAg, PreS1 Ag, PreS1 Ag/HBsAg are risk factors for the occurrence of liver cancer in patients with HBV-related liver cirrhosis.HBsAg, PreS1 Ag, PreS1 Ag/HBsAg have clinical value in predicting the occurrence of liver cancer in patients with HBV-related liver cirrhosis.更多还原