【摘要】 目的 分析人类白细胞抗原(human leukocyte antigen, HLA)Ⅱ类抗原DPB1在肺腺癌(lung adenocarcinoma, LUAD)中的表达、肿瘤免疫浸润及其临床价值。方法 利用Oncomine、Timer、UALCAN、GEPIA等数据库分析HLA-DPB1在LUAD病人中的表达、肿瘤免疫浸润及其临床价值。结果 HLA-DPB1在LUAD组织中低表达，其表达水平与LUAD病人的临床病理特征和肿瘤蛋白53(tumor protein 53,Tp53)突变具有相关性(P<0.05),进一步分析可得到HLA-DPB1的表达下降与肺腺癌病人较差的预后显著相关(P<0.005)。HLA-DPB1的表达水平与LUAD免疫浸润纯度、免疫细胞(B细胞、CD8+T细胞、CD4+T细胞、巨噬细胞、树突状细胞和中性粒细胞)及其标志物水平有关。结论 HLA-DPB1在LUAD组织中的表达水平降低，升高HLA-DPB1表达的LUAD病人倾向于更好的预后。HLA-DPB1的低表达与LUAD病人的免疫浸润细胞有关，提示HLA-DPB1有望成为LUAD病人预后生物标志物和免疫治疗的潜在靶点。更多还原

【Abstract】 Objective To analyze the expression, tumor immunoinvasion and clinical value of Human leukocyte antigen(HLA) class II antigen DPB1 in Lung adenocarcinoma(LUAD) tissues.Methods Oncomine, TIMER,UALCAN,GEPIA and other databases were used to analyze the expression of HLA-DPB1 in LUAD patients, tumor immunoinvasion and its clinical value.Results HLA-DPB1 was low expressed in LUAD tissues, and its expression level was correlated with the clinicopathological characteristics and tumor protein 53(Tp53) mutation in LUAD patients(P<0.05).Further analysis showed that decreased HLA-DPB1 expression was significantly associated with poorer prognosis in patients with lung adenocarcinoma(P<0.005).The expression level of HLA-DPB1 was related to the purity of LUAD immunoinfiltrate, the level of immune cells(B cells, CD8+T cells, CD4+T cells, macrophages, dendritic cells and neutrophils) and their markers.Conclusion The expression level of HLA-DPB1 in LUAD tissues is decreased, and LUAD patients with elevated HLA-DPB1 expression tend to have a better prognosis.The low expression of HLA-DPB1 is associated with immunoinfiltrating cells in LUAD patients, suggesting that HLA-DPB1 is expected to be a prognostic biomarker and a potential target for immunotherapy in LUAD patients.更多还原