【摘要】 目的 探讨缓解期双相情感障碍患者及其一级亲属的人格特征。方法 将60例缓解期双相情感障碍患者设为患者组，患者的一级亲属60名设为亲属组，60名健康志愿者设为健康组，比较3组三维人格问卷评分结果。结果 患者组及亲属组三维人格问卷伤害回避及寻求新奇维度评分均显著高于健康组(P<0.05或0.01),患者组及亲属组比较差异无统计学意义(P>0.05);3组奖赏依赖维度评分两两比较差异无统计学意义(P>0.05)。结论 双相情感障碍患者及其一级亲属的遗传易感性人格特征主要包括寻求新奇、冲动以及悲观，寻求新奇的人格特征可以考虑作为双相情感障碍患者的遗传内表型。更多还原

【Abstract】 Objective To investigate the personality characteristics of patients with bipolar disorder in remission and their first-degree relatives. Methods Sixty patients with bipolar disorder in remission were set as the patient group, 60 first-degree relatives of the patients were set as the relative group, and 60 healthy volunteers were set as the healthy group. The tridimensional personality questionnaire(TPQ) scores of the three groups were compared. Results The injury avoidance and novelty seeking dimension scores in TPQ of the patient group and the relative group were significantly higher than those of the healthy group(P<0.05 or 0.01). There was no significant difference between the patient group and the relative group(P>0.05). There was no significant difference among the three groups in the dimension of reward dependence(P>0.05). Conclusions The personality characteristics of genetic susceptibility of bipolar disorder patients and their first-degree relatives mainly include novelty seeking, impulsiveness, and pessimism. Novelty seeking dimension can be considered as a genetic endophenotype of patients with bipolar disorder.更多还原