【摘要】 CNS炎性脱髓鞘疾病是免疫介导的，可引起视神经、大脑、小脑、脑干、脊髓等部位脱髓鞘病变；包括多发性硬化、视神经脊髓炎谱系疾病(NMOSD)、抗髓鞘少突胶质细胞糖蛋白免疫球蛋白G抗体(MOG-IgG)相关疾病(MOGAD)、胶质纤维酸性蛋白星形细胞病等。特异性诊断生物标志物水通道蛋白4抗体的发现使得NMOSD的病理机制、诊断、鉴别诊断、治疗上取得显著的进步；抗MOG-IgG是MOGAD的致病性抗体；髓鞘碱性蛋白抗体、胶质纤维酸性蛋白抗体等在CNS炎性脱髓鞘疾病诊断与鉴别诊断中均发挥了重要作用。本文综述上述各CNS炎性脱髓鞘疾病相关抗体的研究进展。更多还原

【Abstract】 Inflammatory demyelinating diseases of the CNS are immune-mediated, causing demyelinating lesions of the optic nerve, brain, cerebellum, brainstem, spinal cord. Including multiple sclerosis(MS), neuromyelitis optica spectrum disorders(NMOSD), anti-myelin oligodendrocyte glycoprotein-IgG(MOG-IgG) associated disorders(MOGAD), glial fibrillary acidic protein astrocytopathy, etc. The discovery of specific diagnostic biomarker aquaporin-4 IgG has made significant progress in the pathological mechanism, diagnosis, differential diagnosis and treatment of NMOSD. MOG-IgG is the pathogenic antibody of MOGAD. Myeline basic protein antibody and glial fibrillary acidic protein antibody play important roles in the diagnosis and differential diagnosis of inflammatory demyelinating disease of CNS. This article summaries the progress of the antibodies related to CNS inflammatory demyelinating diseases.更多还原