【摘要】 当前针对慢性乙型肝炎的抗病毒治疗临床治愈率低，并且难以清除cccDNA。随着医药水平的进步，越来越多的新药正处于研发阶段。重点阐述临床试验数据较详尽代表性药物的研发情况。近些年来小干扰RNA、核心蛋白变构调节剂等新药进展较快。从临床试验结果来看，新药进入临床使用仍需一定的时间，并且多药联合方案可能会成为今后的治疗趋势。更多还原

【Abstract】 At present, antiviral therapy for chronic hepatitis B(CHB) has a low clinical cure rate and hardly remove cccDNA. With the progress of medical science, more and more new drugs are in the stage of research and development. This article focuses on the research and development of representative drugs with relatively detailed clinical trial data. Rapid progress has been made in the new drugs such as small-interfering RNA and core protein allosteric modulators in recent years. The results of clinical trials show that it still takes some time for new drugs to enter clinical use, and multi-drug combination therapy may become the trend of treatment in the future.更多还原