【摘要】 胆管癌发病率和死亡率不断上升，研究探索新的治疗靶点具有重要意义。铁死亡是一种新型的铁依赖性细胞氧化损伤的细胞死亡方式，与癌症中的铁代谢及氧化应激失衡密切相关，已成为肿瘤领域的研究热点。介绍了铁死亡相关机制，并在此基础上分析铁死亡参与胆管癌发生发展的研究进展，阐明探讨铁死亡相关调控机制在胆管癌恶性进展过程中的作用具有重要临床价值。更多还原

【Abstract】 The incidence and mortality rates of cholangiocarcinoma(CCA) are increasing constantly, and it is of great importance to explore new therapeutic targets. Ferroptosis, a unique pattern of cell death caused by iron-dependent cellular oxidative injury, is closely associated with iron metabolism and oxidative stress imbalance in cancer and has become a research hotspot in the field of tumor. This article introduces the mechanism of ferroptosis and the research advances in ferroptosis involved in the development and progression of CCA, and it is pointed out that the regulatory mechanism of ferroptosis has an important clinical value in the malignant progression of CCA.更多还原