【摘要】 目的 糖尿病是一种慢性疾病，身体各个系统都有不同程度的损伤。大量研究指出糖尿病患者在新型冠状病毒肺炎(COVID-19)流行期间更加容易感染COVID-19并且更容易出现重症。本研究拟通过Meta分析来探明糖尿病与COVID-19严重程度和死亡率的关联性。方法 使用关键词(1)“COVID-19” OR “SARS-CoV-2” OR “Coronavirus” OR “novel coronavirus” AND “clinical characteristics”(2)“COVID-19” OR “SARS-CoV-2”AND “Diabetes”检索PubMed,Embase和中国知网的数据，筛选截至2021年2月发表的英文和中文期刊论著，提取数据后使用RevMan 5.4进行Meta分析，并使用Stata 12.0评估发表偏倚。结果 共纳入82篇文献，合计35 715例患者。Meta分析结果显示，患糖尿病与COVID-19预后较差有关[OR 2.29 (2.14, 2.46),P<0.01;I~2:52%,P<0.01]。COVID-19患者中糖尿病患者相对非糖尿病患者发生重症[OR 2.40 (2.20, 2.62),P<0.01;I~2:49%,P<0.01]和死亡[OR 2.08 (1.70,2.56),P<0.01;I~2:60%,P<0.01]的风险均升高。结论 糖尿病是影响COVID-19患者的重症率和死亡率升高的一个重要因素，而针对糖尿病如何影响COVID-19预后的确切作用机制亟需进一步研究阐明。更多还原

【Abstract】 Objective Diabetes mellitus(DM) is chronic conditions with devastating multi-systemic complications and may be associated with sensitivity and severe form of Coronavirus Disease 2019(COVID-19). Abundant studies prove that patients with DM are more vulnerable to be infected with COVID-19 and develop severe cases during the prevalence and spread of novel coronavirus pneumonia. The present study intends to conduct meta-analysis to acertain the correlation between DM and severity as well as mortality in patients with COVID-19.Methods The key words(1)“COVID-19” OR “SARS-CoV-2” OR “Coronavirus” OR “novel coronavirus” AND “clinical characteristics”(2)“COVID-19” OR “SARS-CoV-2” AND “Diabetes” were used to search the data available on PubMed, Embase and CNKI, periodicals and articles in English and Chinese published before Feb, 2021 were screened. RevMan 5.4 software was applied after data extraction to perform Meta-analysis, and the Stata 12.0 software was used to assess the publication bias. Results A total of 82 studies which included 35 715 patients were included. Meta-analysis showed that DM was associated with composite poor outcome(OR 2.29 [2.14, 2.46], P< 0.01; I~2: 52%, P<0.01). The risk of severity(OR 2.40 [2.20, 2.62], P< 0.01; I~2: 49%, P<0.01) and mortality(OR 2.08[1.70, 2.56], P< 0.01; I~2: 60%, P<0.01) of DM patients with COVID-19 were elevated than those of patients without DM. Conclusion DM serves as a critical factor to impact the rate of severe cases of COVID-19 and mortality in patients with COVID-19. The mechanism of how DM impacting the prognosis of COVID-19 is required to be further clarified.更多还原