【摘要】 牙髓再生技术是近年来的研究热点，也是根管治疗的良好替代治疗手段。目前对于牙髓再生的研究主要集中在年轻恒牙，而实际上需要接受牙髓治疗的成熟恒牙远多于年轻恒牙，因此牙髓再生技术应用于成熟恒牙有巨大的应用前景。相比年轻恒牙，成熟恒牙的根尖孔已发育完全、解剖结构多样、微环境复杂，牙髓再生难以实现。本文对成熟恒牙在牙髓再生中的根管预备、根管感染控制、干细胞来源及生长因子及支架的应用面临的困难及应对策略作一综述，为成熟恒牙牙髓再生技术的应用提供参考。更多还原

【Abstract】 Pulp regeneration technology is becoming a research hot issue in recent years, and it is also a good alternative treatment for root canal treatment. The current researches on pulp regeneration mainly focused on immature permanent teeth. In fact, there are far more mature permanent teeth that require endodontic treatment than immature permanent teeth. Therefore, pulp regeneration has great application prospects for mature permanent teeth. Compared with immature permanent teeth, mature permanent teeth have difficulties such as fully developed apical foramen, diverse anatomical structures, and complex microenvironment, etc. It is difficult to achieve pulp regeneration. This article reviews the related researches in recent years and discusses the difficulties and coping solutions of mature permanent teeth in pulp regeneration, in order to provide reference for the future development of pulp regeneration technology in mature permanent teeth.更多还原