【摘要】 目的 调查不同孕龄正常单胎活产新生儿的体重状况，获得最新不同孕龄正常新生儿出生体重标准及不同孕龄男、女新生儿出生体重标准，并绘制新生儿出生体重曲线。方法 回顾性分析2014年1月1日至2020年12月31日在云南省第一人民医院产科住院分娩，母亲无并发症和合并症，且活产无严重畸形、无水肿的新生儿出生体重。采用国际上成熟的LMSP方法拟合出生体重曲线，曲线绘制和检验是通过R4.0.2软件中的基于位置、尺度、形状的广义可加模型（GAMLSS）5.3-4软件包进行。结果 （1）获得36 551例正常妊娠26～42周单胎活产新生儿出生体重P3、P10、P25、P50、P75、P90、P97的百分位数值和相应的出生体重曲线图；（2）单胎活产新生儿平均出生体重3 182 g，其中男婴19 072例，占52.18%，平均出生体重3 231 g，女婴17 479例，占47.82%，平均出生体重3 128 g;(3)女性新生儿的平均出生体重小于男婴103 g，差异有统计学意义，P <0.05;(4)小于胎龄儿和大于胎龄儿总体发生率分别为8.98%和9.29%。结论 首次收集云南省第一人民医院近10a正常妊娠26～42周单胎活产新生儿体重，样本量大，数据新，绘制的出生曲线图能准确、客观的评估云南省第一人民医院当前胎儿宫内生长发育状况和围产儿结局，为云南省第一人民医院乃至昆明地区的围产保健工作提供了重要的参考价值。更多还原

【Abstract】 Objective To investigate the weight status of normal single-born live newborns of different gestational ages,obtain the latest birth weight standards of normal newborns of different gestational ages and birth weight standards of male and female newborns of different gestational ages, and draw birth weight curves of newborns. Methods A retrospective analysis was conducted on the birth weight of newborns delivered in the department of Obstetrics of Yunnan First People’s Hospital from January 1,2014 to December 31,2020 without complications, severe malformation or edema during live birth. The birth weight curve was fitted by the internationally established LMSP method. The curve was drawn and checked by the Generalized Additive Model based on Position, Scale and Shape( GAMLSS) 5.3-4 software package in R4.0.2 software. Result The percentile values of birth weight P3,P10,P25,P50,P75,P90,P97 and corresponding birth weight curves were obtained from 36 551 cases of newborns born alive at 26 to 42 weeks of normal gestation. There were 19,072 males(52.18%) and 17,479 females(47.82%),respectively,with an average birth weight of 3 231 g and 3 128 g.The average birth weight of female newborns was 103 g less than that of male newborns,and the difference was statistically significant(P < 0.05). The overall incidence of < gestational age and > gestational age was 8.98% and9.29%,respectively. Conclusion It is the first time to collect the weight of single live newborn born at 26-42 weeks of normal gestation in Yunnan First People’s Hospital in the past 10 years with large sample size and updated data. The birth curve drawn can accurately and objectively evaluate the current intrauterine growth and development status of fetuses and perinatal outcomes in Yunnan First People’s Hospital. It provides important reference value for perinatal health care in Yunnan First People’s Hospital and even in Kunming area.更多还原