节点文献
2011—2020年上海地区肠球菌属细菌耐药性变迁
Antimicrobial resistance surveillance of Enterococcus species in Shanghai, China: results of 2011-2020
【摘要】 目的 了解2011—2020年上海地区临床分离肠球菌属细菌对各类抗菌药物的耐药性变迁。方法 按照上海市细菌真菌耐药监测网统一方案进行肠球菌属细菌的抗菌药物敏感性试验。结果 2011—2020年共分离到非重复肠球菌属细菌113 391株,主要为粪肠球菌与屎肠球菌,分别占54.5%和40.1%。菌株主要分离自尿液标本。10年间粪肠球菌和屎肠球菌在当年肠球菌属细菌中的占比均呈上升趋势。粪肠球菌和屎肠球菌对万古霉素和利奈唑胺的耐药率均保持在较低水平(<2%)。万古霉素耐药肠球菌(VRE)在所有肠球菌属细菌中占比为0.5%(541/113 391),其中万古霉素耐药屎肠球菌与万古霉素耐药粪肠球菌分别占80.2%(434/541)与19.8%(107/541)。结论 肠球菌属临床分离菌对万古霉素和利奈唑胺仍保持较好的敏感性,近年来VRE的分离率呈现下降趋势,提示加强细菌耐药监测对控制耐药细菌的流行播散是十分必要的。
【Abstract】 Objective To investigate the changing susceptibility of Enterococcus to various antibiotics over time from 2011 to 2020 in Shanghai, China. Methods Antimicrobial susceptibility testing was carried out according to a unified protocol. Results were analyzed in accordance with CLSI 2020 breakpoints. Results A total of 113 391 clinical Enterococcus isolates were collected from 2011 to 2020, of which E. faecalis and E. faecium accounted for 54.5% and 40.1%, respectively. Most of strains were isolated from urine specimens. The proportion of E. faecalis and E. faecium in the total clinical isolates increased over the 10-year period from 2011 to 2020. The Enterococcus strains were still highly susceptible to vancomycin and linezolid(overall < 2% resistant). The overall prevalence of vancomycin-resistant Enterococcus(VRE) was 0.5%(541/113 391) in Shanghai, of which vancomycinresistant E. faecium and vancomycin-resistant E. faecalis accounted for 80.2%(434/541) and 19.8%(107/541), respectively. Conclusions Vancomycin and linezolid are still highly active against clinical isolates of Enterococcus in Shanghai. The prevalence of VRE has decreased in recent years. It is necessary to strengthen surveillance of antimicrobial resistance and control dissemination of the resistant strains.
【Key words】 antimicrobial resistance surveillance; Enterococcus; antimicrobial susceptibility testing; changing resistance profile;
- 【文献出处】 中国感染与化疗杂志 ,Chinese Journal of Infection and Chemotherapy , 编辑部邮箱 ,2022年02期
- 【分类号】R446.5
- 【被引频次】1
- 【下载频次】156