【摘要】 琥珀酸是细胞线粒体三羧酸循环的中心代谢产物，同时也是肠道菌群重要的代谢产物。大量证据表明琥珀酸以“信号分子”的方式参与代谢性疾病的发生、发展以及转归。肥胖、非酒精性肝炎、2型糖尿病、代谢性心血管疾病与代谢稳态失衡密切相关，本文综述了琥珀酸与这4种代谢性疾病之间的关系及其作用机制，以期为代谢性疾病的预防和治疗提供新的思路和策略。更多还原

【Abstract】 Succinate is the central metabolite of the mitochondrial tricarboxylic acid cycle and an important metabolite of the intestinal flora. Recent studies have showed that succinate involved in the occurrence, development and outcome of metabolic diseases via “signal molecules”. Obesity, non-alcoholic hepatitis, type 2 diabetes mellitus and metabolic cardiovascular disease are closely related to metabolic homeostasis. This article reviews the relationship between succinate and these four metabolic diseases, and its underlying mechanisms, which might benefit to provide new ideas and strategies for the prevention and treatment of metabolic diseases.更多还原