【摘要】 N6-甲基腺嘌呤(6mA)是存在于真核生物中的表观遗传修饰，通过对线粒体DNA、非编码基因和核糖体DNA等进行修饰，进而动态调控转录。目前研究发现，6mA通过调节线粒体DNA的转录等影响线粒体活性和功能，进而参与代谢性疾病的发生发展。本文探讨6mA调控线粒体功能的机制及其在肥胖、动脉粥样硬化、高血压和癌症等代谢性疾病中的作用，有望为代谢相关疾病的防治提供新思路。更多还原

【Abstract】 N6-methyladenine(6 mA) is an epigenetic modification existed in eukaryotes, which dynamically regulates transcription by modifying mitochondrial DNA, non-coding genes and ribosomal DNA. Current studies have found that 6 mA affects mitochondrial activity and function by regulating mitochondrial DNA transcription, etc., and then participates in the occurrence and development of metabolic diseases. This paper discusses the mechanism of 6 mA regulating mitochondrial function and its role in metabolic diseases such as obesity, atherosclerosis, hypertension and cancer, which is expected to provide new ideas for the prevention and treatment of metabolic-related diseases.更多还原