【摘要】 目的 探讨林芝地区健康人群的糖化血红蛋白(HbA1c)水平并制订参考区间。方法 选取无糖尿病史及其他重大疾病史的1 722例健康人群作为研究对象，使用瑞士罗氏公司Roche c501全自动生化分析仪检测HbA1c水平，分别比较不同民族、不同性别、6个年龄组(≤30岁、>30～40岁、>40～50岁、>50～60岁、>60～70岁、>70岁)之间HbA1c水平的差异。结果 林芝地区藏族人群HbA1c水平高于汉族(P<0.05);不同性别间HbA1c水平差异无统计学意义(P>0.05);藏族、汉族人群HbA1c水平与年龄均呈正相关(r=0.976、0.954,P<0.01);藏族人群≤40岁、>40～50岁、>50岁的HbA1c参考区间分别是4.41%～6.10%、4.56%～6.21%、4.72%～6.51%;汉族人群≤50岁和>50岁的HbA1c参考区间分别是4.41%～6.09%、4.56%～6.32%。结论 林芝地区藏族人群和汉族人群HbA1c水平有差异，均与年龄有关，与性别无关；有必要针对不同人群建立HbA1c水平参考区间。更多还原

【Abstract】 Objective To explore the glycated hemoglobin(HbA1 c) levels in healthy population of Linzhi area, and to establish the reference intervals.Methods A total of 1 722 healthy people with no history of diabetes and other serious diseases were selected as the study subjects, and the HbA1 c level was measured by using the Roche c501 automatic biochemical analyzer.The differences in HbA1 c levels were compared among different nationalities, different genders and 6 age groups(≤30 years old, >30-40 years old, >40-50 years old, >50-60 years old, >60-70 years old, >70 years old).Results The HbA1 c level of the Tibetan population in Linzhi area was higher than that of the Han population(P<0.05).The HbA1 c level had no statistical difference between different genders(P>0.05).The HbA1 c level of Tibetan nationality and Han nationality was positively correlated with the age(r=0.976,0.954,P<0.01).The reference intervals of HbA1 c for Tibetan populations ≤40 years old, > 40-50 years old and >50 years old were 4.41%-6.10%,4.56%-6.21% and 4.72%-6.51% respectively; the reference intervals of HbA1 c in Han populations ≤50 years old and >50 years old were 4.41%-6.09% and 4.56%-6.32% respectively.Conclusion There are differences in HbA1 c levels between Tibetan and Han populations in Linzhi area, which are related to the age and not related to the gender; it is necessary to establish the reference intervals of HbA1 c level for different populations.更多还原