【摘要】 目的 分析健康人群接种新型冠状病毒(SARS-CoV-2)灭活疫苗后抗体水平的变化趋势。方法 选取2021年2月16日至8月17日该院接种SARS-CoV-2灭活疫苗医护人员146例为研究对象，其中男68例，女78例，采用磁微粒化学发光法检测特异性IgM、IgG和中和抗体，采用χ~2检验和t检验进行比较。结果 疫苗接种前，特异性IgM、IgG和中和抗体检测结果均为阴性；接种后60 d特异性IgM、IgG和中和抗体阳性率分别为16.4%、93.1%、89.0%;接种后90 d特异性IgM、IgG和中和抗体阳性率分别为9.5%、90.4%、90.4%;接种后120 d特异性IgM、IgG和中和抗体阳性率分别为4.1%、86.3%、87.6%;接种后180 d,特异性IgM、IgG和中和抗体阳性率分别为0.0%、82.1%、91.7%。在疫苗接种后180 d, IgG和中和抗体阳性率之间差异有统计学意义(χ~2=4.421,P=0.036)。男性在不同时间点的中和抗体竞争率明显低于女性(P<0.05),但阳性率与女性比较差异无统计学意义(P>0.05);年龄分组中，30～<40岁年龄段中和抗体阳性率最高，为96.5%,50～60岁年龄段中和抗体阳性率最低。结论 接种疫苗后，SARS-CoV-2特异性IgM会在机体内存在一段时间，但是IgG和中和抗体会持续存在，疫苗接种能够达到诱导机体免疫系统产生特异性免疫的目的。更多还原

【Abstract】 Objective To analyze the changing trend of antibody levels after inactivated vaccine against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) in healthy population.Methods From February 16 to August 17,2021,totally 146 medical staff who received SARS-CoV-2 inactivated vaccine in Nanyang Central Hospital of Henan Province were collected, including 68 males and 78 females, magnetic particle chemiluminescence method was used to detected specific IgM,IgG and neutralizing antibodies, and χ~2 test and t test were used for comparison.Results Before vaccination, the detection results of specific IgM,IgG and neutralizing antibody were negative.The positive rates of antibodies were 16.4%,93.1% and 89.0% at 60 days after vaccination, and 9.5%,90.4% and 90.4% at 90 days after vaccination, 4.1%,86.3%,87.6% at 120 days after inoculation, and 0.0%,82.1%,91.7% at 180 days after inoculation, respectively.At 180 days after vaccination, the difference between the positive rate of IgG and neutralizing antibody was statistically significant(χ~2=4.421,P=0.036).The neutralizing antibody competition rate of males at different time points was significantly lower than that of females(P<0.05),but the difference between the positive rates was not statistically significant(P>0.05).The positive rate of neutralizing antibody in the age group of 30-<40 years was the highest, which was 96.5%.The positive rate of neutralizing antibody in the age group of 50-60 years was the lowest.Conclusion After vaccination, SARS-CoV-2-specific IgM will exist in the body for a period of time, but IgG and neutralizing antibodies will persist.Vaccination could achieve the purpose of inducing the body′s immune system to produce specific immunity.更多还原