【摘要】 目的 探讨微小RNA-107(miR-107)、系统性免疫性炎症指数(SII)、糖类抗原19-9(CA19-9)在结直肠癌患者中的表达，并分析其与临床病理特征的关系。方法 收集西安高新医院2019年1月至2020年12月收治的结直肠癌患者118例作为癌症组以及结直肠良性肿物患者100例作为良性组，同期收集西安高新医院体检中心体检健康者100例作为对照组。检测3组研究对象的miR-107、SII、CA19-9水平，分析单独检测和联合检测的诊断效能，并探讨其与结直肠癌患者临床病理特征的关系。结果 癌症组患者miR-107、SII、CA19-9水平明显高于良性组和对照组，良性组明显高于对照组，差异均有统计学意义(P<0.05);3项指标联合检测的曲线下面积为0.906,灵敏度和特异度可达90.0%、85.9%。miR-107、SII、CA19-9水平与结直肠癌患者的TNM分期、分化程度、淋巴结转移情况、肝转移情况有关(P<0.05)。结论 miR-107、SII、CA19-9在结直肠癌患者中明显升高，且与不同临床病理特征密切相关，联合检测有助于结直肠癌的早期诊断及病情判断。更多还原

【Abstract】 Objective To investigate the expression of microRNA-107(miR-107),systemic immune inflammation index(SII) and carbohydrate antigen 19-9(CA19-9) in patients with colorectal cancer, and to analyze their relationship with clinicopathological features.Methods A total of 118 patients with colorectal cancer admitted to Xi′an Gaoxin Hospital from January 2019 to December 2020 were included in the cancer group, and 100 patients with benign colorectal masses were included in the benign group.At the same time, 100 healthy subjects in the physical examination center of the hospital were collected as the control group.The levels of miR-107,SII and CA19-9 were detected in the three groups, and the diagnostic efficacy of single detection and combined detection was analyzed, and the relationship between miR-107,SII and CA19-9 and clinicopathological characteristics of colorectal cancer patients were discussed.Results The levels of miR-107,SII and CA19-9 in cancer group were significantly higher than those in benign group and control group, and the benign group were significantly higher than those in control group, with statistical significance(P<0.05).The area under the curve of the three combined tests was 0.906,and the sensitivity and specificity reached 90.0% and 85.9%.The levels of miR-107,SII and CA19-9 were closely correlated with TNM stage, differentiation degree, lymph node metastasis and liver metastasis in colorectal cancer patients(P<0.05).Conclusion miR-107,SII and CA19-9 are significantly increased in patients with colorectal cancer, and are closely related to different clinicopathologic features.Combined detection is helpful for early disease judgment and diagnosis of colorectal cancer.更多还原