【摘要】 目的 探索注射用穿琥宁抗花生四烯酸（AA）诱导的血小板聚集作用。方法 以AA为激动剂，利用血栓弹力图仪检测注射用穿琥宁低、中、高剂量组在健康人血体外给药和SD大鼠体内给药后的血小板抑制率（IR%)；以及纤维蛋白原降解产物（FDP）的含量。同时利用血凝仪测定注射用穿琥宁在SD大鼠体内给药后，凝血因子Ⅱ（FⅡ）、凝血因子Ⅹ（FⅩ）的活性。结果 与空白对照组比较,注射用穿琥宁在体外健康人血的浓度为1.0 mg/mL、2.0 mg/mL时可显著性地抑制血小板的聚集活性,抑制率与药物浓度具有剂量依赖性；FⅩ活性显著性增强、FDP含量显著性增高。同时在SD大鼠体内也看到有抑制血小板聚集的作用。结论 注射用穿琥宁具有抑制血小板聚集活性、增强FⅩ的活性和提高FDP的含量，这为穿琥宁在临床治疗应用中进一步掌握并运用其适应症提供了新的见解。更多还原

【Abstract】 Objective To explore the anti-arachidonic acid(AA)-induced platelet aggregation effect of potassium dehydroandrograpolide succinate for injection(PDSI). Methods Human blood samples and Sprague-Dawley(SD) rats divided into control,aspirin, and CHI groups(low, mid and high) were used to measure the platelet inhibition rate(IR%). And fibrinogen degradation products(FDP), coagulation factor II and X’s activity(FIIa, FXa) in SD rats. Results Compared with the control group, PDSI could significantly inhibit platelet aggregation activity when the blood concentration of healthy human was 1.0 mg/mL and 2.0 mg/mL in vitro, and IR% was dose-dependent with drug concentration. FXa and FDP content was significantly enhanced. At the same time, it can also inhibit platelet aggregation in SD rats. Conclusion PDSI has the activity of inhibiting platelet aggregation, enhancing the activity of FX and increasing the content of FDP, which provides new insights for further mastering and applying the indications of PDSI in clinical application.更多还原