节点文献

CDH11介导的胃癌细胞和成纤维细胞近分泌信号激活YAP/TNC轴促进胃癌转移（英文）

Cadherin 11-mediated juxtacrine interaction of gastric cancer cells and fibroblasts promotes metastasis via YAP/tenascin-C signaling

推荐 CAJ下载
PDF下载
不支持迅雷等下载工具，请取消加速工具后下载。

【作者】倪娇娇；姜明春；陈艳妍；饶显平；姜钧杰；张子震；琚方玉；郭东阳；王博雅；滕理送；王良静；周天华；卓巍；

【Author】 Jiaojiao Ni;Mingchun Jiang;Yanyan Chen;Xianping Rao;Junjie Jiang;Zizhen Zhang;Fangyu Ju;Dongyang Guo;Boya Wang;Lisong Teng;Liangjing Wang;Tianhua Zhou;Wei Zhuo;Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine;Department of Gastroenterology, The Second Affiliated Hospital Zhejiang University School of Medicine;Cancer Center, Zhejiang University;Institute of Gastroenterology, Zhejiang University;Department of Surgical Oncology, The First Affiliated Hospital Zhejiang University School of Medicine;Department of Molecular Genetics, University of Toronto;

【通讯作者】滕理送;王良静;周天华;卓巍;

【机构】 Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine； Department of Gastroenterology, The Second Affiliated Hospital Zhejiang University School of Medicine； Cancer Center, Zhejiang University； Institute of Gastroenterology, Zhejiang University； Department of Surgical Oncology, The First Affiliated Hospital Zhejiang University School of Medicine； Department of Molecular Genetics, University of Toronto；

【摘要】肿瘤细胞与基质微环境的相互作用调控肿瘤转移.肿瘤相关成纤维细胞(CAFs)是肿瘤微环境的主要细胞群,以往报道CAFs通过异常旁分泌信号传导促进肿瘤转移,而CAFs与相邻胃癌细胞是否利用近分泌信号(juxtacrine)促进转移尚不清楚. Cadherins家族(钙黏附蛋白)介导细胞间黏附作用.本文利用TCGA数据库系统研究Cadherins家族,筛选发现cadherin 11(CDH11)在胃癌中表达上调且与预后和分期显著相关,且CDH11表达水平与CAFs主要标志物紧密关联. CDH11介导了CAFs与胃癌细胞之间的黏附互作,从而促进胃癌细胞迁移、克隆形成和肺转移等恶性行为.机制上, CAFs通过CDH11介导的近分泌作用激活胃癌细胞YAP信号通路,上调TNC表达,从而增强胃癌细胞恶性表型.另外,胃癌临床样本数据表明, CDH11, YAP和TNC之间的表达水平显著相关,且CDH11和TNC与胃癌患者不良预后显著相关.该研究揭示了CDH11-YAP-TNC轴在CAFs与胃癌细胞近分泌信号中的作用,为胃癌转移的临床治疗和预后提供了潜在的靶点.更多还原

【关键词】胃癌细胞； CDH11； YAP/TNC；胃癌；近分泌；成纤维细胞；肿瘤转移；恶性行为；肿瘤微环境； cadherin；

【基金】 supported by the National Natural Science Foundation of China (81972276, 31771540, 82173040, 91740205, and 31620103911);Natural Science Foundation of Zhejiang Province (LYY19H310011);Fundamental Research Funds for the Central Universities (2021QNA7004)

【文献出处】 Science Bulletin ,科学通报(英文版) , 编辑部邮箱 ,2022年10期

【分类号】R735.2
【下载频次】76

知网节下载

节点文献中：

本文链接的文献网络图示:

本文的引文网络

节点文献