【摘要】 目的 探讨白细胞(WBC)、中性粒细胞/淋巴细胞比值(NLR)、红细胞分布宽度（RDW）在新型冠状病毒肺炎（COVID-19）中的应用价值。方法 选取201例COVID-19确诊患者作为病例组，并根据疾病严重程度分为普通型、重症、危重型3组，另选取168例健康人群为健康对照组，比较两组的白细胞（WBC）计数、中性粒细胞（NEU）计数、淋巴细胞（LYM）计数、NLR、RDW的差异。绘制受试者工作曲线（ROC），计算敏感度、特异度、曲线下面积（AUC）。结果 与健康对照组相比，COVID-19患者的WBC计数、NEU计数、LYM计数均降低（P<0.01）,NLR升高（P<0.01），两组间RDW差异无统计学意义（P>0.05）。与普通型肺炎相比，重型/危重型肺炎的WBC计数、NEU计数、NLR、RDW均升高（P<0.01）,LYM计数降低（P<0.01）。WBC、NLR联合诊断COVID-19的AUC为0.837(P<0.01)，敏感度为63.2%，特异度为94%。WBC、NLR、RDW三者联合预测重型/危重型COVID-19的AUC为0.908 (P<0.01)，敏感度为77.3%，特异度为93%。结论 联合WBC、NLR及RDW可为COVID-19早期诊断及病情变化评估提供一定的参考，以指导临床用药。更多还原

【Abstract】 Objective To explore the application value of white blood cell(WBC), Neutrophil to lymphocyte ratio(NLR)and red blood cell distribution width(RDW) in the patients with 2019 novel coronavirus pneumonia(COVID-19). Methods A total of 201patients, diagnosed with COVID-19 were selected as the research group and divided into three groups(ordinary, severe, and critically severe pneumonia) according to the disease severity. A total of 168 healthy people were chosen as the control group. The difference of WBC, NEU, LYM, NLR and RDW levels of the two groups were compared. Receiver operating characteristic curve(ROC) was used to calculate sensitivity, specificity, and area under the curve(AUC). Results Compared with control group, WBC count, NEU count, LYM count of COVID-19 patients were significantly reduced(P<0.01), NLR was increased(P<0.01). There was no significant difference in RDW between the two groups(P>0.05). Compared with ordinary COVID-19, WBC count, NEU count,NLR,RDW of severe and critically severe COVID-19 were increased(P<0.01),LYM count was reduced(P<0.01).The AUC of the combination of WBC and NLR for COVID-19 diagnosis was 0.837(P<0.01),with 63.2% sensitivity and 94% specificity. The AUC of the combination of WBC,NLR and RDW for the diagnosis of severe and critically severe COVID-19 was 0.908(P<0.01),with 77.3% sensitivity and 93% specificity. Conclusion Combining detection of WBC, NLR and RDW would help to guide clinical medication.更多还原