【摘要】 目的：研究25-（OH）-D₃水平与儿童毛细支气管炎的关系。方法：以80例毛细支气管炎患儿为病例组，同期100例行健康体检的婴幼儿作为对照组，对比两组儿童25-（OH）-D₃水平，同时调查两组儿童影响维生素D水平相关因素，并进行比较分析。结果：（1）病例组儿童母亲孕期补充维生素D率、近3个月规律补充维生素D率、25-（OH）-D₃水平均低于对照组，差异有统计学意义（P<0.05）。（2）二元Logistic回归结果显示，母亲孕期补充维生素D（P=0.000,OR=0.194,95%CI:0.078,0.481）及25-（OH）-D₃水平（P=0.000,OR=0.958,95%CI:0.944,0.972）是细支气管炎发生的独立保护性因素。结论：毛细支气管炎患儿血清25-（OH）-D₃水平较正常儿童明显偏低，25-（OH）-D₃水平与毛细支气管炎发病相关，母亲孕期及婴幼儿规律补充维生素D制剂可能有助于降低毛细支气管炎的发生。更多还原

【Abstract】 Objective To study the relationship between 25-（OH）-D₃ level and bronchiolitis in children.Method 80 children with bronchiolitis were selected as the case group, and 100 healthy children were selected as the control group. The levels of 25-（OH）-D₃ in the two groups were determined, and the related factors of vitamin D nutrition were investigated by questionnaire. The data of the two groups were statistically analyzed.Results（1） Compared with the control group, the rate of vitamin D supplementation during pregnancy, the rate of regular vitamin D supplementation in recent 3 months and the level of 25-（OH）-D₃ in the case group were lower, and the differences were statistically significant（P<0.05）.（2）Binary logistic regression results showed that vitamin D supplementation during pregnancy（P=0.000, OR=0.194, 95%CI:0.078,0.481） and 25-（OH）-D₃ levels（P=0.000, OR=0.958, 95%CI:0.944,0.972） was an independent protective factor for the occurrence of bronchiolitis.Conclusion The serum level of 25-（OH）-D₃ in children with bronchiolitis is significantly lower than that in normal children. The level of 25-（OH）-D₃ is correlated with the incidence of bronchiolitis. Regular supplementation of vitamin D during pregnancy and in infants may help reduce the incidence of bronchiolitis.更多还原