【摘要】 目的：探讨α1-抗胰凝乳蛋白酶（α1-AT）多态性与慢性阻塞性肺疾病（COPD）易感性的关系。方法：选取收治的COPD患者110例（COPD组）,同时选取健康志愿者110例作为对照组，采用PCR-限制性片段长度多态性方法检测α1-AT基因rs1243166序列基因多态性。结果：COPD组和对照组α1-AT基因rs1243166序列基因型分布比较差异有统计学意义（P<0.05）,其中COPD组基因型GG和等位基因G比例分别为38.18%和60.00%,高于对照组；GG型患者一秒用力呼气量占用力肺活量比值（FEV₁/FVC）为（48.89±9.92）%,明显低于AA型和GA型患者，差异有统计学意义（P<0.05）;AA型和GA型患者FEV₁/FVC比较差异无统计学意义（P>0.05）。结论：α1-AT基因rs1243166序列基因多态性与COPD易感性有关，基因型GG患者肺功能较差。更多还原

【Abstract】 Objective To explore the relationship between the polymorphism of α1-antichymotrypsin（α1-AT） and the susceptibility of chronic obstructive pulmonary disease（COPD）.Method 110 COPD patients（COPD group） treated in our hospital were selected, and 110 healthy volunteers were selected as control group, the rs1243166 gene polymorphism of α1-AT gene was detected by PCR-restriction fragment length polymorphism.Results There was significant difference in genotype distribution of rs1243166 sequence between COPD group and control group（P<0.05）, the proportion of genotype GG and allele G in COPD group were 38.18% and 60.00%, respectively, which were higher than that in control group; The ratio of forced expiratory volume per second to forced vital capacity（FEV₁/FVC） in GG patients was（48.89±9.92）%, which were significantly lower than that in AA and GA patients（P<0.05）; There were no significant difference in FEV₁/FVC between AA and GA patients（P>0.05）.Conclusion The rs1243166 gene polymorphism of α1-AT gene is related to the susceptibility of COPD, and the lung function of GG patients is poor.更多还原