【摘要】 目的 利用瞬时弹性成像技术检测肝硬度值评价恩替卡韦治疗慢性乙型肝炎的临床效果。方法 利用瞬时弹性成像技术动态监测实验组30例(恩替卡韦+常规护肝治疗)和对照组30例(常规护肝治疗)慢性乙型肝炎患者治疗12、24、48周后硬度值、肝功能复常率的变化。结果 实验组治疗12、24、48周后肝硬度值均明显低于治疗前，差异具有统计学意义(P<0.05);治疗24和48周后，实验组肝硬度值明显低于同期对照组，肝功能复常率明显高于同期对照组，差异均有统计学意义(P<0.05)。结论 瞬时弹性成像技术能动态、定量监测肝纤维化的程度，可用于评估肝脏疾病治疗效果；恩替卡韦抗病毒治疗慢性乙型肝炎效果明显，对抑制肝纤维化具有一定的临床疗效。更多还原

【Abstract】 Objective To evaluate the clinical effect of entecavir in the treatment of chronic hepatitis B. Methods The changes of hardness value and normalization rate of liver function in 30 patients with chronic hepatitis B in the experimental group(entecavir+routine liver protection treatment) and 30 patients in the control group(routine liver protection treatment) were dynamically monitored by transient elastic imaging technology after 12,24 and 48 weeks of treatment. Results The liver hardness of the experimental group after 12,24 and 48 weeks of treatment was significantly lower than that before treatment(P<0.05);After 24 and 48 weeks of treatment, the liver hardness value of the experimental group was significantly lower than that of the control group in the same period, and the normalization rate of liver function was significantly higher than that of the control group in the same period(P<0.05). Conclusion Transient elastography can dynamically and quantitatively monitor the degree of liver fibrosis and can be used to evaluate the therapeutic effect of liver diseases; Entecavir is effective in the treatment of chronic hepatitis B and has a certain clinical effect on inhibiting liver fibrosis.更多还原