【摘要】 DNA甲基化是表观遗传学重要的组成部分之一。异常的DNA甲基化被认为是导致前列腺癌发生的重要因素，DNA高甲基化可导致与DNA修复、细胞黏附、细胞周期、细胞凋亡相关的抑癌基因部分失活，而DNA低甲基化可激活癌基因，两者共同影响前列腺癌的形成和发展。目前，由于前列腺癌DNA甲基化可逆的特性，其已成为研究的热点，故本研究对前列腺癌DNA甲基化研究作一综述，以期为前列腺癌的诊断和预后提供新的生物标记物以及治疗靶点。更多还原

【Abstract】 DNA methylation is one of the important components of epigenetics. Abnormal DNA methylation is considered to be an important factor leading to the occurrence of prostate cancer,DNA hypermethylation can cause partial inactivation of tumor suppressor genes related to DNA repair,cell adhesion,cell cycle and apoptosis,while DNA hypomethylation can activate oncogenes,both of which jointly affect the formation and development of prostate cancer. At present,DNA methylation in prostate cancer has become a research hotspot due to its reversible nature. Therefore,this study summarizes the research on DNA methylation in prostate cancer,in order to provide new biomarkers and therapeutic targets for the diagnosis and prognosis of prostate cancer.更多还原