【摘要】 目的 探讨肝癌组织中干扰素诱导的跨膜蛋白1(IFITM1)的表达及其在病理分级中的意义。方法 采用免疫组织化学法检测IFITM1在肝癌组织中的表达并分析其与病理分级的关系。结果 IFITM1在肝癌组织中的表达低于正常肝组织，差异有显著统计学意义(P <0.01);肝癌组织病理分级与IFITM1表达呈正相关，肝癌组织的分化程度越高，IFITM1表达水平越高，肝癌的恶性程度越低;而肝癌组织的分化程度越低，IFITM1表达水平越低，肝癌的恶性程度越高，差异有显著统计学意义(P <0.01)。结论 IFITM1在肝癌组织中低表达，不同病理分级中IFITM1的表达不同，可能与肝癌的发生有关。更多还原

【Abstract】 Objective To investigate the expression of interferon-induced transmembrane protein 1(IFITM1) in liver cancer tissues and its significance in pathological grade. Methods The expression of IFITM1 in liver cancer tissues was detected by immunohistochemistry method and its relationship with pathological grade was analyzed. Results The expression of IFITM1 in liver cancer tissues was lower than that in the normal liver tissues,and the difference was statistically significant(P < 0. 01). The pathological grade of liver cancer tissues was positively correlated with IFITM1 expression. The higher the differentiation degree of liver cancer tissues,the higher the expression level of IFITM1,and the lower the malignancy degree of liver cancer. The lower the differentiation degree of liver cancer tissues,the lower the expression level of IFITM1,and the higher the malignancy degree of liver cancer,and the differences were statistically significant(P < 0. 01).Conclusion The expression of IFITM1 is low in liver cancer tissues,and the expression of IFITM1 varies in different pathological grades,which may be related to the occurrence of liver cancer.更多还原