【摘要】 目的：分析妊娠晚期孕妇阴道微生态环境与不良妊娠结局关系。方法：选取2019年1月-2020年3月在本院产前检查的70例妊娠晚期孕妇临床资料，均采集阴道分泌物评价阴道微生态环境，按照检测结果分为阴道微生态正常组和异常组，比较两组不良妊娠结局。结果：正常组22例(31.4%),异常组48例(68.6%),其中10例(14.3%)单纯微生态失调、14例(20.0%)细菌性阴道病(BV)、9例(12.9%)滴虫性阴道炎(TV)、7例(10.0%)念珠性阴道炎(VVC)、8例(11.4%)混合性感染。异常组早产(29.2%)、宫内感染(33.3%)、胎膜早破(22.9%)、新生儿低体重(31.3%)、新生儿窒息(29.2%)、新生儿感染(25.0%)发生率均高于正常组(4.6%、0、0、0、4.6%、0)(P<0.05),产褥感染、产后出血发生率两组无差异(P>0.05);BV、TV、VVC及混合感染孕妇早产、宫内感染及新生儿低体重发生率均高于单纯微生态失调(P<0.05),胎膜早破、产褥感染、产后出血、新生儿窒息、新生儿感染发生率与单纯微生态失调未见差异(P>0.05)。结论：妊娠晚期孕妇阴道微生态环境异常发生率较高，异常孕妇发生不良妊娠结局风险增加，提示临床产科应重视妊娠晚期孕妇阴道微生态环境，预防不良妊娠结局。更多还原

【Abstract】 Objective: To explore the correlation between vaginal microecology of pregnant women during the third trimester of pregnancy and their adverse pregnancy outcomes. Methods: The clinical data of 70 pregnant women during the third trimester of pregnancy from January 2019 to May 2020 were selected in this study. The vaginal secretions of these women collected to evaluate their vaginal microecological environment. These women were divided into the women with abnormal vaginal microecology in study group and the women with normal vaginal microecology in control group. The adverse pregnancy outcomes of the women were compared between the two groups. Results: Among these 70 women, there were 22(31.4%) women with normal vaginal microecology, and 48(68.6%) women with abnormal vaginal microecology, which included 10(14.3%) cases with simple abnormal microecology, 14(20.0%) cases with BV, 9(12.9%) cases with TV, 7(10.0%) cases with VVC, and 8(11.4%) cases with mixed infection. The incidences of premature delivery(29.2%), intrauterine infection(33.3%), premature rupture of membranes(22.9%), low neonatal weight(31.3%), neonatal asphyxia(29.2%), and neonatal infection(25.0%) in the study group were significantly higher than those(4.6%, 0, 0, 0, 4.6%, and 0) in the control group(P<0.05), and there were no significant differences in the incidences of puerperal infection and postpartum hemorrhage of the women between the two groups(P>0.05). The incidences of premature delivery, intrauterine infection, and low neonatal weight of the women with BV, TV, VVC, or mixed infection were significantly higher than those of the women with simple abnormal vaginal microecology(P<0.05), but there were no significant differences in the incidences of premature rupture of membranes, puerperal infection, postpartum hemorrhage, neonatal asphyxia, and neonatal infection between the women with BV,TV,VVC,or mixed infection and the women with simple abnormal vaginal microecology(P>0.05).Conclusion:The rate of the abnormal vaginal microecological environment of the pregnant women during the third trimester of pregnancy is high,which is closely related to their adverse pregnancy outcomes.It is important to pay attention to the vaginal microecological environment of the pregnant women during the third trimester of pregnancy,so as to prevent their adverse pregnancy outcomes.更多还原