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罗沙司他治疗肾性贫血的研究进展
Research progress on roxadustat treatment for renal anemia
【摘要】 肾性贫血是导致慢性肾脏病(CKD)疾病进展的的独立危险因素。新型治疗肾性贫血药物罗沙司他利用机体对低氧的自然反应,激活低氧诱导信号通路,同时调控内源性促红细胞生成素(EPO)生成并改善铁代谢,有效纠正血红蛋白水平,综合调节红细胞生成。
【Abstract】 Renal anemia is an independent risk factor for progression of chronic kidney disease(CKD).Roxadustat, a novel medicine for renal anemia, utilizes the body’s native response to hypoxia for activating the hypoxia-induced signaling pathway, regulating endogenous erythropoietin(EPO) production and improving iron metabolism, so effectively corrects hemoglobin level and comprehensively regulates erythropoiesis.
【关键词】 罗沙司他;
肾性贫血;
脯氨酰羟化酶抑制剂;
低氧诱导因子;
慢性肾脏病;
【Key words】 roxadustat; renal anemia; prolyl hydroxylase inhibitor; hypoxia-inducible factor; chronic kidney disease;
【Key words】 roxadustat; renal anemia; prolyl hydroxylase inhibitor; hypoxia-inducible factor; chronic kidney disease;
【基金】 湖北省卫生健康委员会联合基金(青年人才项目)(WJ2019H561)
- 【文献出处】 基础医学与临床 ,Basic and Clinical Medicine , 编辑部邮箱 ,2022年09期
- 【分类号】R692.5;R556
- 【下载频次】152