【摘要】 目的 探讨连云港市高血压人群内脏脂肪指数(visceral adiposity index, VAI)水平与新发高尿酸血症(hyperuricemia, HUA)的相关性，为HUA的早期预防以及疾病控制提供参考和依据。方法 本研究来自中国脑卒中一级预防试验的尿酸子研究，共10 513名尿酸正常[尿酸<357μmol/L (6 mg/dL)]的高血压患者纳入分析。本研究主要终点为新发HUA,定义为末次随访男性血尿酸浓度≥417μmol/L(7 mg/dL)或女性血尿酸浓度≥357μmol/L(6 mg/dL)。结果 本研究共纳入了10 513例尿酸正常的高血压受试者。平均随访4.4年之后，共有1 642(15.6%)例受试者发生了HUA。分析结果显示，与VAI<2.98(第一至三分位)的受试者相比，VAI≥2.98(第四分位)的受试者新发HUA的发生风险升高(13.8%vs. 21.1%;OR:1.17;95%CI:1.01～1.36;P<0.001)。此外，分层分析显示这种风险关系独立于组成VAI的四个指标(交互作用均有P>0.05)。结论 在连云港市的高血压人群中，VAI越大的人群患上HUA的风险越高。更多还原

【Abstract】 Objective The relation between visceral adiposity index（VAI） and new-onset hyperuricemia remains largely understudied. This study seeks to further investigate the association between VAI and the risk of hyperuricemia by examining possible effect modifies in hypertensive patients. Methods A total of 10 513 hypertensive patients with normal uric acid（UA） concentrations [<357 μmol/L（6 mg/dL）] who participated the UA Sub-study of the China Stroke Primary Prevention Trial（CSPPT） were enrolled. Our primary outcome was new-onset hyperuricemia, which was defined as a UA concentration ≥417 μmol/L（7 mg/dL） in men or ≥357 μmol/L（6 mg/dL） in women at the exit visit. Results Over a median follow-up of 4.4 years, 1 642（15.6%） participants developed new-onset hyperuricemia. When VAI was assessed as quartiles, a significantly higher risk of new-onset hyperuricemia was found in participants in quartile 4（≥2.98; OR:1.17; 95% CI: 1.01-1.36） compared with those in quartile 1-3（<2.98）. Furthermore, the positive relation was independent of abnormal VAI components or numbers of abnormal VAI components(all P_interactions>0.05). Conclusions There is a positive relationship between baseline VAI and the risk of new-onset hyperuricemia in a sample of Chinese hypertensive individuals.更多还原