【摘要】 目的 分析类风湿性关节炎患者联合应用羟氯喹及甲氨蝶呤治疗的临床效果。方法 方便选取2019年4月—2021年5月福建医科大学附属龙岩市第一医院接受治疗的62例类风湿性关节炎患者，随机将患者分为两组，各31例。对照组患者采用甲氨蝶呤治疗，观察组患者采用羟氯喹与甲氨蝶呤联合治疗，比较两组患者治疗前后疼痛度、晨僵时间、红细胞沉降率（ESR）、类风湿因子（RF）、C反应蛋白（CRP）以及临床疗效。结果 治疗前，两组患者疼痛度评分及晨僵时间差异无统计学意义（t=0.106、0.533,P=0.916、0.596）；治疗后，观察组VAS评分较对照组更低，且晨僵时间更短，差异有统计学意义（t=26.535、9.428,P<0.001）。治疗前，两组患者ESR、RF及CRP水平差异无统计学意义（t=0.013、0.029、0.032,P=0.990、0.977、0.974），治疗后观察组ESR、RF及CRP水平较对照组低，差异有统计学意义（t=2.729、41.287、13.029,P<0.05）。观察组临床总有效率（96.77%）显著高于对照组（74.19%），差异有统计学意义（χ~2=4.679,P=0.031）。结论 类风湿性关节炎患者联合应用羟氯喹及甲氨蝶呤治疗可促进病情缓解，有效减轻疼痛度并能够优化实验室指标，临床应用价值较高。更多还原

【Abstract】 Objective To analyze the clinical effect of combined treatment with hydroxychloroquine and methotrexate in patients with rheumatoid arthritis. Methods A total of 62 patients with rheumatoid arthritis were treated from the First Longyan Hospital affiliated to Fujian Medical University from April 2019 to May 2021 were conveniently selected. The patients were randomly divided into two groups, with 31 cases in each. The patients in the control group were provided with methotrexate treatment, and the patients in the observation group were provided with the combined treatment of hydroxychloroquine and methotrexate. The pain degree, morning stiffness time, erythrocyte sedimentation rate(ESR), rheumatoid factor(RF), C-reactive protein(CRP) and clinical efficacy were compared before and after treatment. Results There was no statistically significant difference in pain score and morning stiffness time between two groups before treatment(t=0.106, 0.533, P=0.916, 0.596). After treatment, the VAS score of the observation group was lower than those in the control group, and the time of morning stiffness was shorter, and the difference was statistically significant(t=26.535, 9.428, P<0.001). There was no statistically significant difference in the levels of ESR, RF and CRP between two groups before treatment(t=0.013, 0.029, 0.032, P=0.990, 0.977, 0.974). After treatment, the levels of ESR, RF and CRP in the observation group were lower than those in the control group, and the difference was statistically significant(t=2.729, 41.287, 13.029, P<0.05). The total clinical effective rate in the observation group(96.77%) was significantly higher than that in the control group(74.19%), and the difference was statistically significant(χ~2=4.679, P=0.031). Conclusion The combined application of hydroxychloroquine and methotrexate in patients with rheumatoid arthritis can promote the remission of the disease, effectively reduce the pain degree and optimize the laboratory indicators, which has high clinical application value.更多还原