【摘要】 目的 评估小儿哮喘采用常规治疗方案结合孟鲁司特的有效性。方法 方便选择医院于2020年8月—2021年8月接诊的98例哮喘患儿为研究对象，按照双盲法分为两组。参照组（n=49）提供常规治疗方案，观察组（n=49）提供常规治疗方案结合孟鲁司特治疗。比较两组哮喘患儿治疗有效性。结果 观察组憋喘缓解时间（2.66±0.75）d、咳嗽缓解时间（2.76±0.35）d、肺部啰音缓解时间（4.36±1.52）d、肺部哮鸣音缓解时间（2.11±1.05）d均短于参照组，差异有统计学意义(P<0.05)。观察组治疗有效率（97.96%）高于参照组，差异有统计学意义(χ~2=7.127,P=0.007)。观察组血清CysLTs(27.89±7.89)ng/mL、血清免疫球蛋白E(255.46±63.15)mg/L均低于参照组，差异有统计学意义(P<0.05)。观察组日间哮喘控制评分（2.74±1.52）分、夜间哮喘控制评分（2.03±0.87）分均低于参照组，差异有统计学意义(P<0.05)。观察组FEV1(1.74±0.52)L、FVC(1.30±0.10)L、FEV1/FVC(86.91±4.45)%、PEF(3.23±0.52)L/s均大于参照组，差异有统计学意义(P<0.05)。结论 小儿哮喘采用常规治疗方案结合孟鲁司特可以增进疗效，缩短症状恢复时间，还可以改善患儿的肺功能指标。更多还原

【Abstract】 Objective To evaluate the effectiveness of routine treatment regimen combined with montelukast in children with asthma. Methods A total of 98 asthmatic children admitted by the hospital from August 2020 to August2021 were conveniently selected and divided into two groups according to double-blind method. The control group(n=49) was provided with conventional treatment plan, and the observation group(n=49) was provided with conventional treatment plan combined with montelukast. The therapeutic effectiveness of the two groups was compared.Results The relief time of asthma(2.66±0.75) d, cough(2.76±0.35) d, lung rales(4.36±1.52) d, lung asthma(2.11±1.05) d in the observation group were shorter than those in the control group, the difference was statistically significant(P <0.05). The effective rate of observation group(97.96%) was higher than that of control group, the difference was statistically significant(χ~2=7.127, P=0.007). Serum CysLTs(27.89±7.89) ng/mL and immunoglobulin E(255.46±63.15) mg/L in the observation group were lower than those in the control group, the difference was statistically significant(P<0.05). The asthma control score of observation group in daytime(2.74±1.52) points and at night(2.03±0.87) points was lower than that of control group, the difference was statistically significant(P<0.05). FEV1(1.74±0.52) L, FVC(1.30±0.10) L, FEV1/FVC(86.91±4.45) %, PEF(3.23±0.52) L/s in the observation group were higher than those in the control group, the difference was statistically significant(P<0.05). Conclusion Montelukast combined with routine treatment for children with asthma can improve the curative effect, shorten the recovery time of symptoms, and improve the lung function index of children.更多还原