【摘要】 目的 观察珍枣胶囊对阴虚火旺型中老年失眠伴抑郁状态患者的改善作用。方法 将我院阴虚火旺型中老年失眠伴抑郁状态患者60例随机分为观察组与对照组各30例。对照组口服艾司唑仑治疗,治疗组口服珍枣胶囊治疗。比较两组中医症候积分、匹兹堡睡眠质量指数(PSQI)、汉密尔顿抑郁量表17项(HAMD-17)、血清中炎症因子的水平。结果 治疗后两组中医症候积分、PSQI评分、HAMD-17评分均下降且观察组低于对照组(P<0.05);两组白细胞介素-2(IL-2)、白介素-6(IL-6)水平均下降且观察组IL-2、IL-6水平低于对照组(P<0.05)。结论 珍枣胶囊可以有效改善阴虚火旺型中老年失眠患者的睡眠质量,同时可以缓解患者的抑郁状态,降低血清中炎症因子的水平。更多还原

【Abstract】 Objective To observe the improvement effect of Zhenzao Capsules on middle-aged and elderly patients with insomnia accompanied by depression due to yin deficiency and fire.Methods Sixty cases of middle-aged and elderly patients with insomnia accompanied by depression of yin deficiency and fire vigour type were randomly divided into observation group and control group with 30 cases each.Control group took estazolam and treatment group took Zhenzao Capsules.TCM syndrome scores Pittsburgh Sleep Quality Index(PSQI),and 17 items of Hamilton Depression Scale(HAMD-17) and the level of inflammatory factors in the serum were compared between the two groups.Results After treatment,the TCM syndrome score,PSQI score,and HAMD-17 score of both groups decreased,and observation group was lower than control group,the difference was statistically significant(P<0.05);after treatment,the levels of interluekin(IL)-2 and IL-6 in both groups decreased,which were lower in observation group than control group(P<0.05).Conclusion Zhenzao Capsules can effectively improve the sleep quality of middle-aged and elderly patients with insomnia due to yin deficiency and fire,and alleviate the patients’ depression and reduce the level of serum inflammatory factors.更多还原