【摘要】 目的 探讨重症腺病毒肺炎(SAP)患儿血清巨噬细胞炎症蛋白-1α(MIP-1α)、转化生长因子-β1(TGF-β1)、白细胞介素-10(IL-10)水平及其临床意义。方法 选择腺病毒肺炎(AP)患儿118例，分为SAP组57例和非SAP组61例，将SAP患儿根据预后分为有效组和无效组。比较各组治疗前、治疗4天、治疗7天血清MIP-1α、TGF-β1、IL-10水平，及其对SAP诊断和预后的效能。结果 与治疗前比较，MIP-1α、TGF-β1、IL-10水平治疗后两组均随时间逐步下降，且治疗前、治疗4天、治疗7天SAP组均高于非SAP组(P<0.05)。治疗后有效组MIP-1α、TGF-β1、IL-10水平低于无效组(P<0.05)。MIP-1α、TGF-β1、IL-10三者联合检测对SAP诊断和预后预测的效能最高(P<0.05)。结论 SAP患儿血清MIP-1α、TGF-β1、IL-10水平高，三者联合检测对SAP诊断和预后预测有重要价值。更多还原

【Abstract】 Aim To investigate the serum levelsand clinical significance of serum macrophage inflammatory protein-1α(MIP-1α),transforming growth factor-β1(TGF-β1) and interleukin-10(IL-10) in children with severe adenovirus pneumonia(SAP). Methods 118 children with adenovirus pneumonia(AP) were selected and divided into SAP group(n=57) and non-SAP group(n=61). Patients with SAP were divided into effective group and ineffective group according to their prognosis. The serum levels of MIP-1α, TGF-β1 and IL-10 in each group were compared before treatment, 4 days after treatment and 7 days after treatment, and their efficacy on the diagnosis and prognosis of SAP were compared. Results Compared with before treatment, the levels of MIP-1α, TGF-β1 and IL-10 in the two groups decreased gradually with time after treatment, and their levels in the SAP group were higher than those in the non-SAP group before treatment, 4 days and 7 days after treatment(P<0.05). After treatment, the levels of MIP-1α, TGF-β1 and IL-10 in the effective group were lower than those in the ineffective group(P<0.05). The combined detection of MIP-1α, TGF-β1 and IL-10 had the highest efficacy in the diagnosis and prognosis of SAP(P<0.05). Conclusion MIP-1α,TGF-β1 and IL-10 are in high level in the serum of children with SAP,and the combined detection of MIP-1α,TGF-β1 and IL-10 is of great value for the diagnosis and prognosis of SAP.更多还原