【摘要】 6-（{[6-（三氟甲基）吡啶-3-基]甲基}氨基）吡啶-3-甲醛是抗癌药物培西达替尼的关键中间体。本文以6-氨基烟酸甲酯和6-三氟甲基烟醛为原料，经还原胺化、还原和氧化共三步反应合成目标化合物，产物结构经MS、IR、¹H NMR、¹³C NMR分析表征；同时探讨了不同条件对反应的影响。在最佳工艺条件下，产物总产率达58.6%。该合成路线具有原料廉价易得、条件温和、操作简便等优点，可望实现规模化生产。更多还原

【Abstract】 6-（{[6-（Trifluoromethyl）pyridin-3-yl]methyl}amino）pyridine-3-carbaldehyde is used as the key intermediate of the anticancer drug pexidartinib.In this article, the title compound was synthesized from methyl 6-aminonicotinate and 6-（trifluoromethyl）nicotinaldehyde through three steps of reductive amination reaction, reduction reaction and oxidation reaction.The product was characterized by MS,IR,¹HNMR and ¹³CNMR.At the same time, the influence of different conditions on the reaction was also discussed.Under the best technological conditions, the total yield of the product reached 58.6%.The synthetic route had the advantages of cheap raw materials, mild conditions and simple operation, which could realize large-scale production.更多还原