【摘要】 目的 探讨中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）与非瓣膜性心房颤动（NVAF）患者缺血性脑卒中（IS）风险的关系。方法 选择2019年1月至2020年6月于郑州大学第一附属医院心血管病医院住院的239例NVAF患者为研究对象。根据是否有IS史将患者分为NVAF+IS组（n=112）和NVAF组（n=127）。比较两组CHA₂DS₂-VASc评分、合并疾病情况、中性粒细胞计数（NC）、淋巴细胞计数（LC）、血小板计数（PLT）及NLR、PLR等临床资料。采用logistic回归分析NLR、PLR与IS风险的相关性，绘制受试者工作特征（ROC）曲线以评估NLR、PLR对IS的预测价值。结果 NVAF+IS组平均年龄、CHA₂DS₂-VASc评分、NC、PLT、NLR、PLR均高于NVAF组，阵发性心房颤动患者比率、LC低于NVAF组（P<0.05）。多因素logistic回归分析结果显示，NLR、PLR与IS风险呈正相关（P<0.05）。受试者工作特征曲线显示，NLR、PLR对IS风险有一定的预测价值（P<0.001）。结论 NLR、PLR与NVAF患者IS风险呈正相关，NLR、PLR可以较好地预测NVAF患者发生IS的风险。更多还原

【Abstract】 Objective To investigate the relationship between neutrophil/lymphocyte ratio（NLR）, platelet/lymphocyte ratio（PLR） and the risk of ischemic stroke（IS） in patients with non-valvular atrial fibrillation（NVAF）.Methods A total of 239 patients with NVAF who were hospitalized in the Cardiovascular Hospital of the First Affiliated Hospital of Zhengzhou University from January 2019 to June 2020 were selected as the research subjects. They were divided into NVAF+IS group（n=112） and NVAF group（n=127） according to whether they had a history of IS. The CHA₂DS₂-VASc score, comorbidities, neutrophil count（NC）, lymphocyte count（LC）, platelet count（PLT）, NLR, PLR and other clinical data were compared between the two groups. Logistic regression analysis was used to evaluate the correlation between NLR,PLR and IS risk, and the receiver operating characteristic（ROC） curve was drawn to evaluate the predictive value of NLR and PLR to IS.Results The average age, CHA₂DS₂-VASc score, NC, PLT, NLR, and PLR of the NVAF+IS group were higher than those of the NVAF group, and the proportion of paroxysmal atrial fibrillation and LC were lower than those of the NVAF group（P<0.05）. Multivariate logistic regression analysis showed that NLR, PLR and IS risk were positively correlated（P<0.05）. Receiver operating characteristic analysis showed that NLR and PLR had certain predictive value for IS risk（P<0.001）.Conclusion NLR and PLR are positively correlated with IS risk in NVAF patients. NLR and PLR can better predict the risk of IS in patients with NVAF.更多还原