【摘要】 目的 探讨急诊血管内治疗（EVT）对急性缺血性脑卒中（AIS）患者炎症因子和神经激素的影响。方法 选取2021-01—2022-01信阳市中心医院急诊收治的148例AIS患者为研究对象，根据治疗方式分为静脉溶栓组（66例）及EVT组（82例）。对比2组患者临床疗效及治疗前后炎症因子[白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、神经激素[血管紧张素Ⅱ（AngⅡ）、醛固酮（ALD）、心钠素（ANP）]水平差异。结果 EVT组临床疗效总有效率明显优于静脉溶栓组（92.68%vs81.82%，χ2=4.041,P<0.05）。治疗前，2组血清IL-2、IL-6、TNF-α、AngⅡ、ALD、ANP水平比较无差异（P>0.05）；治疗后，2组血清IL-2、IL-6、TNF-α、AngⅡ、ALD、ANP水平均低于治疗前，EVT组[（4.55±0.92）ng/L、（7.27±2.02）ng/L、（7.52±2.15）ng/L、（75.78±14.75）ng/L、（127.21±20.03）ng/L、（67.39±16.69）pg/mL]低于静脉溶栓组[（5.68±1.04）ng/L、（8.86±2.37）ng/L、（8.49±2.20）ng/L、（83.52±17.41）ng/L、（160.61±22.76）ng/L、（79.71±17.45）pg/mL](t=7.006、4.406、2.700、2.927、9.487、4.374,P<0.05)。结论 急诊EVT治疗AIS疗效确切，能降低炎症因子及神经激素水平，值得临床应用。更多还原

【Abstract】 Objective To investigate the effects of emergency endovascular therapy(EVT)on inflammatory factors and neurohormones in patients with acute ischemic stroke(AIS).Methods A total of 148 AIS patients admitted to emergency department from January 2021 to January 2022 were selected as the study subjects,and were divided into intravenous thrombolysis group(66 cases)and EVT group(82 cases)according to treatment methods.The clinical efficacy and the levels of inflammatory factors[INTERleukin-2(IL-2),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],neurohormone[angiotensinⅡ（AngⅡ）,aldosterone(ALD),atrial natriuretic peptide(ANP)]before and after treatment were compared between 2 groups.Results The total effective rate of clinical efficacy in EVT group(92.68% vs 81.82%)was significantly better than that in intravenous thrombolysis group（χ2=4.041,P<0.05）. Before treatment,there was no difference in the levels of serum IL-2,IL-6,TNF-α,AngⅡ,ALD and ANP between the two groups(P>0.05).After treatment,the serum levels of IL-2,IL-6,TNF-α,AngⅡ,ALD and ANP in both groups were lower than those before treatment,And EVT group[(4.55±0.92)ng/L,(7.27±2.02)ng/L,(7.52±2.15)ng/L,(75.78±14.75)ng/L,(127.21±20.03)ng/L,(67.39)±16.69)pg/mL]was lower than the intravenous thrombolysis group[(5.68±1.04)ng/L,(8.86±2.37)ng/L,(8.49±2.20)ng/L,(83.52±17.41)ng/L,(160.61±22.76)ng/L,(79.71±17.45)pg/mL](t=7.006,4.406,2.700,2.927,9.487,4.374,P<0.05).Conclusion Emergency EVT has a definite curative effect in the treatment of AIS,and can reduce the levels of inflammatory factors and neurohormones,which is worthy of clinical application.更多还原