【摘要】 目的 探讨降钙素原和中性粒细胞/淋巴细胞比值（Neutrophil lymphocyte ratio,N/L）在小儿肺炎早期诊断中的应用价值。方法 选择112例肺炎患儿作为研究对象，采用罗氏CobasE411电化学发光方法检测PCT，采用全自动血细胞仪对中性粒细胞计数（N）及淋巴细胞计数（L）进行检测，然后按照公式计算NLR。比较对照组与患儿组（低、中、高风险组）PCT及NLR水平；存活组与死亡组患儿相关指标水平；PCT联合NLR诊断小儿肺炎的特异性与敏感度。结果 PSI各组（低危组、中危组及高危组）PCT及NLR水平均显著高于对照组，且随着PSI分值升高，PCT及NLR水平也随之显著提升差异均具有统计学意义（F值分别为6.562、15.592,P值分别为0.028、0.000）；死亡组患儿血清PCT及NLR水平均分别显著高于存活组（P<0.05）；经对PCT基NLR两项指标ROC曲线分析，结果表明两项指标曲线以下面积差异均具有统计学意义（P<0.01）;PCT取0.86ng/mL时的敏感度为92.0%，特异度为81.2%;NLR取11.28时的敏感度为71.9%，特异度为77.8%。结论 PCT与NLR对小儿肺炎病情及其预后中具有较高的临床评估价值，可作为判定小儿重症肺炎发病程度及预后评估的简单指标。更多还原

【Abstract】 Objective To investigate the value of Neutrophil lymphocyte ratio(N/L)in the early diagnosis of pediatric pneumonia.Methods 112 children with pneumonia admitted to our hospital from August 2018 to August 2019 were selected as research objects.PCT was detected by roche CobasE411 electrochemical luminescence method,and the neutrophil count(N)and lymphocyte count(L)were detected by automatic hematometer.Then the NLR was calculated according to the following formula:NLR=N/L.PCT and NLR levels were compared between the control group and the children group(low,medium and high risk groups).The levels of relevant indicators in the survival group and the death group;Specificity and sensitivity of PCT combined with NLR in diagnosis of pediatric pneumonia.Results(1)PCT and NLR levels in each PSI group(low risk group,medium risk group and high risk group)were significantly higher than those in the control group,and with the increase of PSI score,PCT and NLR levels also increased significantly,and the differences were statistically significant(F values were 6.562 and 15.592,P values were 0.028 and 0.000,respectively).(2)serum PCT and NLR levels in the death group were significantly higher than those in the survival group(all P<0.05).(3)the ROC curves of two indicators of pct-based NLR were analyzed,and the Results showed that:the area differences below the curves of the two indicators were statistically significant(all P<0.01).When the PCT was 0.86ng/mL,the sensitivity was 92.0% and the specificity was 81.2%.The sensitivity and specificity of NLR at 11.28 were 71.9% and 77.8% respectively.Conclusion PCT and NLR have high clinical value in evaluating the condition and prognosis of infantile pneumonia.更多还原