【摘要】 目的 探讨β地中海贫血患儿T淋巴细胞亚群、自然杀伤(NK细胞、B淋巴细胞水平的变化及临床意义。方法 选取2017年3月至2020年3月深圳市宝安区人民医院收治的84例β地中海贫血患儿为研究组，并选取同期84例健康儿童为对照组。检测并比路两组儿童T淋巴细胞亚群(CD3~+细胞、CD4~+细胞、CD8~+细胞、CD4~+/CD8~+比值)、NK细胞、B淋巴细胞(CD19~+细胞)水平。结果 研究组患儿的CD3~+细胞、CD4~+细胞、CD4~+/CD8~+比值分别为(56.62±13.23)%、(32.05±7.72)%、0.97±0.24，明显低于对照组的(69.55±17.22)%、(43.44±10.96)%、1.79±0.45,CD8~+细胞水平为(33.41±8.23)%，明显高于对照组的(24.34±6.27)%，差异均有统计学意义(P<0.05)；研究组患儿的NK细胞水平为(13.33±3.26)%，明显低于对照组的(24.30±5.74)%,CD19~+细胞水平为(26.04±6.17)%，明显高于对照组的(12.46±3.08)%，差异均有统计学意义(P<0.05)。结论 β地中海贫血患儿的T淋巴细胞亚群、NK细胞、B淋巴细胞水平与健康儿童相比有明显差异，临床加强对T淋巴细胞亚群、NK细胞、B淋巴细胞水平的检测，有利于患儿病情诊断、免疫状况评估及针对性干预治疗。更多还原

【Abstract】 Objective To investigate the changes and clinical significance of T lymphocyte subsets, natural killer cells, and B lymphocytes in children with β-thalassemia. Methods A total of 84 children with β-thalassemia who were admitted to Shenzhen Bao’an District People’s Hospital from March 2017 to March 2020 were selected as the study group, and 84 healthy children during the same period were selected as the control group. The levels of T lymphocyte subsets(CD3~+cells, CD4~+cells, CD8~+cells, CD4~+/CD8~+ratio), NK cells, and B lymphocytes(CD19~+cells) were detected and compared between the two groups. Results The CD3~+cells, CD4~+cells, and CD4~+/CD8~+ratio of the children in the study group were(56.62±13.23)%,(32.05±7.72)%, 0.97±0.24, which were significantly lower than(69.55±17.22)%,(43.44±10.96)%, 1.79±0.45 of the control group; the level of CD8~+cells was(33.41±8.23)%, which was significantly higher than(24.34±6.27)% of the control group; the differences were statistically significant(P<0.05). The NK cells level of the children in the study group was(13.33±3.26)%, which was significantly lower than(24.30±5.74)% of the control group; the level of CD19~+cells was(26.04±6.17)%, which was significantly higher than(12.46±3.08)% of the control group; the differences were statistically significant(P<0.05). Conclusion The levels of T lymphocyte subsets,NK cells, and B lymphocytes in children with β-thalassemia are significantly different from those in healthy children.To strengthen the detection of T lymphocyte subsets, NK cells, and B lymphocytes in clinical practice is beneficial to the diagnosis of the disease, the evaluation of immune status and targeted intervention treatment in children withβ-thalassemia.更多还原