【摘要】 目的 探讨交泰丸加味脐疗对原发性失眠患者睡眠焦虑、抑郁的改善作用。方法 选取原发性失眠患者112例，按照随机数字表法分为A、B两组，每组56例。A组口服右佐匹克隆片治疗，B组采用交泰丸加味脐疗。比较两组患者治疗2周后的临床疗效，治疗前及治疗2周后的中医证候积分、汉密尔顿焦虑量表(HAMA)评分、抑郁量表(HAMD)评分、匹兹堡睡眠质量指数(PSQI)评分，以及治疗期间不良反应发生情况。结果 治疗2周后，B组患者总有效率为89.29%,高于A组的73.21%(P<0.05)。治疗2周后，两组患者的中医证候积分、HAMA评分、HAMD评分及PSQI评分均较治疗前降低，且B组的上述评分均低于A组(均P<0.05)。B组未见不良反应发生，A组不良反应发生率为10.71%,B组不良反应发生率低于A组(P<0.05)。结论 相较于口服右佐匹克隆片，采用交泰丸加味脐疗治疗原发性失眠患者的疗效更佳，可更有效地改善患者的失眠相关症状，提高睡眠质量，明显缓解患者焦虑、抑郁情绪，且无不良反应，安全性高。更多还原

【Abstract】 Objective To explore the improvement effect of modified Jiaotai Pill umbilical therapy on sleep anxiety and depression in patients with primary insomnia. Methods A total of 112 patients with primary insomnia were selected, and they were assigned to group A or group B according to the random number table method, with 56 cases in each group. Group A was orally administrated with Dexzopiclone Tablets for treatment, and group B received modified Jiaotai Pill umbilical therapy. The 2-week post-treatment clinical efficacy, pre-and 2-week post-treatment Traditional Chinese symptom scores, Hamilton Anxiety Scale(HAMA) scores, and Hamilton Depression Scale(HAMD) scores, Pittsburgh Sleep Quality Index(PSQI) scores, and adverse reactions during treatment were compared between the two groups. Results After 2 weeks of treatment, the total effective rate of group B was 89.29%, which was higher than that of group A(73.21%, P<0.05). After 2 weeks of treatment, the Traditional Chinese symptom scores, and scores of HAMA, HAMD, and PSQI of the two groups were lower than those before treatment, and group B exhibited lower scores mentioned above as compared with group A(all P<0.05). No adverse reaction occurred in group B, whereas the incidence rate of adverse reactions of group A was 10.71%, and the incidence rate of adverse reactions in group B was lower than that in group A(P<0.05). Conclusion Compared with oral administration of Dexzopiclone Tablets, the application of Jiaotai Pill umbilical therapy to the treatment of patients with primary insomnia exerts a preferable efficacy, which can effectively ameliorate patients′ symptoms related to insomnia, improve the quality of sleep, and significantly relieve patients′ anxiety and depression, without adverse reaction and with a high safety.更多还原