【摘要】 目的 观察高强度间歇训练对射血分数保留的心力衰竭(HFpEF)患者心肺功能和生活质量的影响。方法 将80例HFpEF患者随机分为观察组和对照组，各40例。观察组在常规药物治疗基础上采用高强度间歇训练，对照组在常规药物治疗基础上采用中等强度持续训练，两组均治疗6个月。比较两组患者治疗前后的左室射血分数(LVEF)、最大摄氧量、无氧阈值及明尼苏达心力衰竭生活质量问卷(MLHFQ)评分，并观察两组患者治疗期间主要心血管不良事件的发生情况。结果 治疗6个月后，两组患者的LVEF、最大摄氧量、无氧阈值均高于治疗前，MLHFQ评分均低于治疗前，且观察组患者的最大摄氧量和无氧阈值均高于对照组，MLHFQ评分低于对照组(均P<0.05)。两组患者治疗期间的主要心血管不良事件发生率比较，差异无统计学意义(P>0.05)。结论 相较于中等强度持续训练，采用高强度间歇训练辅助治疗HFpEF更有利于提高患者的心肺耐力，改善生活质量，且安全性良好。更多还原

【Abstract】 Objective To observe the effects of high-intensity interval training on cardiopulmonary function and quality of life in patients with heart failure with preserved ejection fraction(HFpEF). Methods Eighty patients with HFpEF were randomly divided into observation group and control group, with 40 cases in each group. The observation group underwent high-intensity interval training on the basis of conventional drug treatment, whereas the control group underwent moderate-intensity continuous training on the basis of conventional drug treatment. Both groups were treated for six months. Left ventricular ejection fraction(LVEF), maximal oxygen uptake, anaerobic threshold, and the Minnesota Living with Heart Failure Questionnaire(MLHFQ) scores for quality of life before and after the treatment were compared between the two groups, and the incidence of major adverse cardiovascular events during the treatment was observed in the two groups.Results After six months of the treatment, LVEF, maximal oxygen uptake, and anaerobic threshold were higher and MLHFG scores were lower in the two groups as compared with those before the treatment; moreover, the observation group yielded higher maximal oxygen uptake and anaerobic threshold and lower MLHFQ scores than the control group(all P<0.05). There was no statistically significant difference in the incidence rate of major adverse cardiovascular events during the treatment between the two groups(P>0.05). Conclusion Compared with moderate-intensity continuous training, high-intensity interval training in the adjuvant treatment of HFpEF is more beneficial to improve patients′ cardiopulmonary endurance and quality of life, with favorable safety.更多还原