【摘要】 丁酸钠(NaBu)是一种低分子量挥发性脂肪酸钠盐，属于组蛋白去乙酰化酶抑制剂(HDACIs),可引起细胞周期停滞或促进细胞分化，最终诱导细胞凋亡，此效应对癌细胞有特异性，对正常细胞影响较小。NaBu的这种独特性质使其成为有前途的抗癌药物。本文对NaBu诱导癌细胞凋亡的分子机制作一概述。更多还原

【Abstract】 Sodium butyrate(NaBu) is a low-molecular weight four-carbon chain volatile fatty acid, which belongs to histone deacetylase inhibitors(HDACIs).NaBu can cause cell cycle arrest or promote cell differentiation, and ultimately induce cell apoptosis.These effects are specific for tumor but not for regular cells.This unique nature of NaBu makes it become a promising drug for anti-cancer therapy.This review outlines the molecular events that accompany the antitumor action of NaBu.更多还原