【摘要】 目的：探讨加味破格救心汤2号对阳虚水泛兼血瘀型慢性肺心病患者血液流变学和心功能的影响。方法：将慢性肺心病阳虚水泛兼血瘀型患者73例按照随机数字表法分为观察组38例和对照组35例。对照组予纠正心衰“金三角”方案药物、降肺动脉压及吸氧治疗，观察组在对照组治疗的基础上联合加味破格救心汤2号治疗。治疗2周后评价两组患者治疗前后血浆黏度、全血黏度、红细胞压积和B型利钠肽（B-type natriuretic peptide,BNP）、6 min步行运动实验（6 minutes walking test,6 MWT）、NYHA分级。结果：治疗后观察组患者血浆黏度、全血黏度均低于对照组，差异有统计学意义（P<O.05），红细胞压积与对照组比较差异无统计学意义（P>O.05）。两组患者BNP、6 MWT、NYHA分级均较治疗前改善，差异有统计学意义（P<O.05）；与对照组比较，观察组BNP、NYHA分级改善更明显，差异有统计学意义（P<O.05）。结论：在常规治疗的基础上联用加味破格救心汤2号可改善阳虚水泛兼血瘀型肺心病患者的血液流变学和心功能，有效防止肺动脉血栓形成。更多还原

【Abstract】 Objective: To explore the influence of modified Poge Jiuxin Tang No.2 on hemorheology and cardiac function in patients with chronic pulmonary heart disease of Yang deficiency and water flooding, and blood stasis pattern. Methods: All 73 patients were divided into 38 cases of the observation group and 35 cases of the control group according to random number table method. The control group was given the drugs of "golden triangle" programme to correct heart failure, pulmonary artery pressure reduction and oxygen inhalation treatment,and the observation group took modified Poge Jiuxin Tang No.2 based on the therapy the control group accepted.To assess plasma viscosity, whole blood viscosity, hematocrit(HCT), BNP, 6 MWT and the classification of NYHA before and after treatment in both groups after two weeks of treatment. Results: After treatment, the observation group was lower than the control group in plasma viscosity and whole blood viscosity, and the difference had statistical meaning(P<0.05), the difference had no statistical meaning when the observation group was compared with the control group in HCT(P>0.05). BNP, 6MWT and the classification of NYHA improved compared with before treatment in the two groups, and the difference had statistical meaning(P<0.05); compared with the control group, the improvements of BNP and the classification of NYHA in the observation group were more notable, and the difference had statistical meaning(P<0.05). Conclusion: Modified Poge Jiuxin Tang No.2 could improve hemorheology and cardiac function in patient with chronic pulmonary heart disease of Yang deficiency and water flooding, and blood stasis pattern, which could effectively prevent the pulmonary thrombosis.更多还原