【摘要】 目的 观察回阳软坚汤加味联合三联抗菌药物治疗非哺乳期乳腺炎肿块期阳虚痰凝证的临床疗效。方法 将62例非哺乳期乳腺炎肿块期阳虚痰凝证患者采用随机数字表法分为对照组和治疗组，各31例。对照组给予三联抗菌药物(异烟肼0.30 g、利福平0.45 g、乙胺丁醇0.75 g,均晨起空腹顿服)治疗；治疗组在对照组治疗方法的基础上给予回阳软坚汤加味口服，每日1剂。2组均以28 d为1个疗程，疗程之间间隔2 d,共治疗3个疗程。比较2组治疗28 d、治疗3个月后的临床疗效，以及治疗前和治疗28 d、治疗3个月后的乳腺肿块平均直径(手工测量和超声检查结果)、临床症候积分。结果 治疗28 d及3个月后，2组乳腺肿块平均直径(手工测量和超声检查结果)及临床症候积分明显降低，与同组治疗前比较差异均有统计学意义(P<0.01),且治疗组降低更明显，与对照组治疗后同期比较差异均有统计学意义(P<0.05或P<0.01)。治疗28 d后，治疗组总有效率为96.77%(30/31),对照组为70.97%(22/31),2组比较差异有统计学意义(P<0.05);治疗3个月后，2组总有效率均为100.00%(31/31),差异无统计学意义(P>0.05),但治疗组治愈率[32.26%(10/31)]明显高于对照组[16.13%(5/31)],2组比较差异有统计学意义(P<0.05)。结论 回阳软坚汤加味联合三联抗菌药物治疗非哺乳期乳腺炎肿块期阳虚痰凝证疗效显著，能明显改善患者的临床症状，缩小乳腺肿块，作用优于单纯采用三联抗菌药物治疗，且见效快，值得临床推广应用。更多还原

【Abstract】 Objective To observe the clinical efficacy of modified Huiyang Ruanjian Tang(回阳软坚汤) combined with triple antibiotic in the treatment of non-lactating mastitis with yang deficiency and phlegm coagulation syndrome at swelling stage.Methods 62 cases of non-lactating mastitis with yang deficiency and phlegm coa-gulation syndrome at swelling stage were divided into control group and treatment group according to random number table method, with 31 cases in each group.The control group was given triple antibiotic(isoniazid 0.30 g, rifampicin 0.45 g, ethambutol 0.75 g, all of which were taken as a dose on an empty stomach in the morning);The treatment group was given modified Huiyang Ruanjian Tang orally on the basis of the treatment of the control group, one dose a day.The two groups took 28 days as a course of treatment, with an interval of 2 days between courses, and a total of 3 courses of treatment.The clinical efficacy of the two groups after 28 days and 3 months of treatment were compared, as well as the average diameter of breast mass(manual measurement and ultrasonic examination results) and clinical symptom scores before of treatment and after 28 days and 3 months of treatment were compared.Results After 28 days and 3 months of treatment, the average diameter of breast masses(manual measurement and ultrasonic examination results) and clinical symptom scores in the two groups were significantly reduced compared with those in the same group before treatment(P<0.01),and the reduction in the treatment group was more significant than that in the control group at the same period after treatment(P<0.05 or P<0.01).After 28 days of treatment, the total effective rate was 96.77%(30/31) in the treatment group and 70.97%(22/31) in the control group.The difference between the two groups was statistically significant(P<0.05);After 3 months of treatment, the total effective rate of both groups was 100.00%(31/31),with no statistically significant difference(P>0.05),but the cure rate of the treatment group[32.26%(10/31)] was significantly higher than that of the control group[16.13%(5/31)],with statistically significant difference between the two groups(P<0.05).Conclusion It has marked efficacy, can ob-viously improve the clinical symptoms of patients, shrink the breast mass to use modified Huiyang Ruanjian Tang combined with triple antibiotic in the treatment of non-lactating mastitis with yang deficiency and phlegm coagulation syndrome at swelling stage.The treatment is better than that of using triple antibiotic alone, and a rapid onset, which is worthy of clinical promotion and application.更多还原