【摘要】 目的：掌握赣州市人感染猪链球菌病疫情的流行病学及病原学特征，为制订防治对策提供科学依据。方法：对2019—2021年赣州市报告的人感染猪链球菌病病例开展流行病学调查，采集标本开展病原学和药敏检测。结果：2019—2021年赣州市共报告人感染猪链球菌病例7例，无死亡病例。病例年龄47～70岁，中位数为65岁，以中老年为主；男女比为5∶2；职业以农民和餐饮食品从业人员为主。7例病例中5例（71.43%）发病前有明确猪接触史，接触或加工猪肉产品时无个人防护；7例病例均为脑膜脑炎型，急性发病，临床表现为发热、神志不清或昏迷等意识障碍。7例病例均为猪链球菌2型，多位点序列分型结果显示大余为ST7型，宁都为ST1型。最小核心基因（MCG）分型显示两株分离株均属于Group1。药敏实验结果显示，大余和宁都分离株对美罗培南、头孢克肟、加替沙星和万古霉素表现为敏感，对复方新诺明、红霉素、克林霉素、阿奇霉素、卡那霉素、链霉素和四环素均表现为耐药。大余分离株对庆大霉素表现为敏感，宁都分离株对庆大霉素表现为耐药。结论：赣州市人感染猪链球菌病疫情呈散发，无防护措施下洗切市售猪及其副产品为高风险行为，病原分离株已对部分抗生素耐药，各部门需加强监测预警和宣传教育，降低疫情的危害。更多还原

【Abstract】 Objective :To grasp the epidemiological and etiological characteristics of the humaninfected with streptococcus suis in Ganzhou City,and to provide scientific basis for the formulation of prevention and control measures.Methods:An epidemiological investigation was conducted on the cases of human infection with streptococcus suis reported in Ganzhou from 2019 to 2021,and samples were collected for etiology and drug susceptibility testing.Results :From 2019 to2021,a total of 7 cases of human infection with streptococcus suis were reported in Ganzhou City,with no deaths. The age of the cases was from 47 to 70 years old,with a median of 65 years old,mainly middle-aged and elderly people;the male-to-female ratio was 5∶2;the occupations were mainly farmers and catering and food practitioners. In the 7 cases,5patients(71. 43%)had a clear history of contact with pigs before the onset,and had no personal protection when contacting or processing pork products. All cases were of meningoencephalitis type,with acute onset,and the clinical manifestations were fever,confusion or coma and other disturbances of consciousness. All cases were streptococcus suis type 2,and the results of multi-locus sequence typing showed thatit was ST7 type in Dayu and ST1 type in Ningdu. The minimal core gene(MCG)typing showed that both isolates belonged to Group1. The drug susceptibility test results showed that the isolates from Dayu and Ningdu were sensitive to meropenem,cefixime,gatifloxacin and vancomycin,and to cotrimoxazole,erythromycin,clindamycin,azithromycin,kana resistance to tetracycline,streptomycin,and tetracycline. Dayu isolates were sensitive to gentamicin,while Ningdu isolates were resistant to gentamicin.Conclusion :The outbreak of streptococcus suis infection among people in Ganzhou City was sporadic. Washing and cutting commercial pigs and their by-products without protective measures was a high-risk behavior. Pathogen isolates were resistant to some antibiotics. It is very important to strengthen monitoring,early warning,publicity and education to reduce the harm of the epidemic.更多还原