【摘要】 本研究探讨磁共振成像T2WI、弥散加权成像(DWI)在直肠癌新辅助治疗疗效的评估价值。选取直肠癌患者92例,给予新辅助治疗,比较治疗前后T2WI、DWI参数变化。治疗无效患者治疗后肿瘤绝对信号值(SIT)明显高于治疗有效患者(P<0.05),而肿瘤绝对信号值减低率(SITRR)、治疗后肿瘤相对信号值(SIT/M)、肿瘤相对信号值减低率(SIT/MRR)明显低于治疗有效患者(P<0.05);治疗无效患者治疗后表观扩散系数(ADC)值、ADC变化值明显低于治疗有效患者(P<0.05);治疗后SIT、SITRR、SIT/MRR预测治疗有效的ROC曲线下面积分别为0.671、0.950和0.879(P<0.05);治疗后ADC值、ADC变化值预测治疗有效的ROC曲线下面积分别为0.717和0.977(P<0.05)。磁共振T2WI图像参数、ADC在预测直肠癌新辅助治疗疗效中有较高的应用价值。更多还原

【Abstract】 This study explores the evaluation value of the efficacy of T2 WI, dispersion-weighted imaging(DWI) in the neoadjuvant treatment of rectal cancer. 92 patients with rectal cancer treated were selected and given neoadjuvant therapy, the changes of T2 WI and DWI parameters before and after treatment were compared. The signal intensity of tumor value(SIT) after treatment of the patients with ineffective treatment was significantly higher than that of the patients with effective treatment(P<0.05), the signal intensity of tumor reduction rate(SITRR), signal intensity of tumor/muscle value(SIT/M) after treatment and signal intensity of tumor/muscle reduction rate(SIT/MRR) were significantly lower than those of effective patients(P<0.05). After treatment, apparent diffusion coefficient(ADC) value and ADC change value in ineffective patients were significantly lower than those of effective patients(P<0.05). The area under the ROC curve of SIT after treatment, SITRR and SIT/MRR to predicts therapeutic efficacy was 0.671, 0.950 and 0.879, respectively(P<0.05). The areas under the ROC curve of ADC value after treatment and ADC change value to predicts therapeutic efficacy were 0.717 and 0.977, respectively(P<0.05). Magnetic resonance T2 WI image parameters and ADC have high application value in predicting the efficacy of neoadjuvant therapy for rectal cancer.更多还原