【摘要】 成像技术的迅速发展使科学家和临床医生能够准确地了解癌症的发病机制和病理过程,并根据患者的情况制定个性化的治疗策略.将各种成像与治疗试剂整合为一体的癌症诊疗平台,可以同时用于癌症的诊断和治疗,受到了广泛的关注.金属-有机框架材料(MOFs)是由有机配体和金属离子/离子簇自组装而成的一种有趣而独特的多孔有机-无机杂化材料.由于其易于后修饰、孔隙和结构可设计、功能可调等特点,已被证明具有成为癌症诊疗药物负载平台的巨大潜力.本文介绍了将诊疗药物负载到MOFs中的策略,并综合评述了在磁共振成像、计算机断层扫描成像、正电子发射断层扫描成像、光学成像和光声成像等多种成像技术指导下, MOFs作为癌症诊断和治疗平台的发展概况.此外,还讨论了MOFs在癌症诊疗和临床转化方面当前面临的挑战和发展前景.更多还原

【Abstract】 The rapid development of imaging technologies allows scientists and clinicians to understand the pathogenesis and pathological processes of cancer accurately and to personalize treatment strategies based on a patient’s condition. Cancer theranostic platforms combining various imaging and therapeutic agents into one entity for the diagnosis and treatment of cancer simultaneously have attracted great attention and been widely studied. Metal-organic frameworks(MOFs)are an interesting and unique porous organic-inorganic hybrid materials constructed by the self-assembly of organic linkers and metal ions/ion clusters. It has demonstrated great potential to be a platform for carrying cancer theranostic agents due to its unique characteristics,such as easy post-modification,adjustable porosity,tunable functionality,and designable topology. In this review,we focused on the strategies of incorporating theranostic agents into MOFs carriers and summarized the developments of MOFs as cancer theranostic platforms for diagnosis and treatment of cancer guided by various imaging technologies,including magnetic resonance imaging,X-ray computed tomography imaging,positron emission tomography imaging,optical imaging,and photoacoustic imaging. Moreover,the current challenges and perspectives of MOFs for cancer theranostics and their clinical translation were also addressed.更多还原