【摘要】 目的 探讨正常反应患者应用拮抗剂方案添加拮抗剂同时添加注射用尿促性素（HMG）的体外受精-胚胎移植（IVF-ET）结局。方法 本研究将2020年1月至2021年10月正常反应患者320在本中心行拮抗剂方案助孕，按照随机数字表法分为对照组168例和研究组152例。研究组在添加拮抗剂的同时添加HMG37.5～75 IU，对照组不添加HMG，对两组的IVF结局等进行前瞻性对照研究。结果 研究组较对照组HCG注射日雌二醇（E₂）、获卵数、受精率、D₃可用胚胎数、D₃优胚数、着床率、临床妊娠率增加，比较差异具有统计学意义（P<0.05）。结论 在正常反应患者中应用拮抗剂方案，添加思则凯同时添加HMG可改善体外受精-胚胎移植的结局。更多还原

【Abstract】 Objective To analyze the effect of GnRH antagonist protocol when adding antagonist adding HMG as well in patients with normal ovarian response in vitro fertilization-embryo transplantation（IVF-ET）. Methods In this study, 320 patients with normal response from January 2020 to October 2021 received the antagonist program to assist pregnancy in our center, and were divided into 168 cases in the control group and 152 cases in the study group according to the random number table method.The research group was supplemented with antagonists while adding urinary gonadotropin（HMG） 37.5-75IU for injection, and the control group was not supplemented with HMG), and a prospective control study was conducted on the IVF outcomes of the two groups. Results Compared with the control group, the estradiol（E₂） on the day of HCG injection, the number of eggs retrieved,the fertilization rate, the number of D₃ available embryos, the number of D₃ excellent embryos, the implantation rate, and the clinical pregnancy rate increased in the study group, and the differences were statistically significant（P<0.05）. Conclusion The application of antagonist regimen in patients with normal response, the addition of Szekai and the addition of urinary gonadotropin（HMG） for injection can improve the outcome of in vitro fertilization-embryo transfer.更多还原