【摘要】 本文采用溶剂挥发法和悬浮法制备了染料木素-盐酸水苏碱共晶，将其与PVP通过球磨法制得固体分散体，运用XRD等手段进行表征，并采用紫外-可见吸收光谱考察了共晶及其固体分散体的溶解性能。实验结果表明，染料木素-盐酸水苏碱共晶与PVP形成固体分散体后，以无定型的形式高度分散在PVP载体中，染料木素在水中的溶解度有所提高；当染料木素-盐酸水苏碱共晶与PVP的质量比为1:5时，固体分散体中染料木素在水中的溶解度是染料木素的2.4倍，有利于改善染料木素的生物利用度。更多还原

【Abstract】 In this paper, genistein-stachydrine hydrochloride cocrystals were prepared by solvent evaporation method and suspension method, and the solid dispersions of the cocrystals and PVP were prepared by ball milling method. They were characterized by X-ray powder diffraction. Also the solubility of the cocrystals and the solid dispersions was investigated by UV-Vis absorption spectrometry. The results indicated that the genistein-stachydrine hydrochloride cocrystals were highly dispersed in PVP in amorphous form. In addition, the solubility of genistein in the solid dispersion of genistein-stachydrine hydrochloride cocrystals and PVP was improved. When the ratio of genistein-stachydrine hydrochloride cocrystals and PVP was 1:5, the solubility of genistein in the solid dispersion of the cocrystals and PVP was 2.4 times that of genistein, which would be conducive to improve the bioavailability of genistein.更多还原