【摘要】 目的 探索水合氯醛对儿童睡眠脑电图的影响。方法 研究纳入2019年11月8日—2021年9月1日于四川大学华西第二医院进行脑电图检查的5岁以下儿童共计250例，根据检查前是否服用水合氯醛分为服药组和未服药组，其中服药组167例，男女比例113∶54，平均年龄（30.78±17.43）月龄；未服药组83例，男女比例60∶23，平均年龄（33.12±17.10）月龄，两组年龄、性别无统计学差异。采用定量脑电图方法分别对两组脑电图各种波形功率所占的百分比进行比较分析。结果 服药组脑电图β波占比（2.76±4.03）%，未服药组脑电图β波占比（1.59±1.21）%，两组间具有显著性差异，服药组睡眠脑电图β波占比更大。结论 水合氯醛可能会引起睡眠脑电图β快波增多，可能会影响脑电图的判读、影响疾病的诊断。更多还原

【Abstract】 Objective To explore the effect of chloral hydrate on sleep Electroencephalogram(EEG) in children.Methods A total of 250 children under the age of 5 underwent EEG examination in West China Second University Hospital from Nov.8, 2019to Sep.1,2021 were enrolled and divided into medication group or non-medication group according to whether they took chloral hydrate before the examination. Among them, 167 patients, the average age of whom was(33.12±17.10) months, were in the medication group, with a male to female ratio of 113:54. 83 cases were in the unmedicated group, the ratio of male to female was 60:23, and the average age was(33.12±17.10) months. There was no statistical difference in age and gender between the two groups. Quantitative EEG method was used to compare and analyze the percentages of the power of various EEG waveforms in the two groups. Results: The proportion of EEG beta waves in the medication group was(2.76±4.03)%, and the proportion of EEG beta waves in the non-medication group was(1.59±1.21)%. There was a significant difference between the two groups. The proportion of sleep EEG beta waves in the medication group is higher. CONCLUSION: Chloral hydrate may cause the increase of β fast waves in sleep EEG, which may affect the interpretation of EEG and the diagnosis of diseases.更多还原